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  • AI-1 | 75483-04-4 | Structure | Supplier
    AI-1 (75483-04-4) is a novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1...

  • AI-3 | 882288-28-0 | Structure | Supplier
    AI-3 (882288-28-0) is an activator of antioxidant response element (ARE) which induces cytoprotective genes in human cells. It alkylates Keap1 at Cys151 and is reactive toward additional cysteines at higher concentrations...

  • Oltipraz | Nrf2 activator
    Oltipraz (64224-21-1) upregulates the transcription factor NRF2 and prevents insulin resistance and obesity induced by high fat diet in C57BL/6J mice1. Attenuates the progression of fibrosis in a rat model of nonalcoholic...

  • Tryptanthrin | Immunomodulator; IDO2 inhibitor
    Tryptanthrin (13220-57-0) is an indoloquinazoline alkaloid found in various plant species and possessing intriguing pharmacological activities.1Suppresses activation of BV2 microglia cells following LPS treatment and reduces...

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