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BiochemicalTargets

Transcription factors

Transcription factors are proteins that control the transcription of genetic information from DNA to messenger RNA by binding to various DNA sequences. There are over 1500 factors in the human genome that control cell division, growth, and death as well as many other functions. Focus Biomolecules offers many modulators of transcription factors such as PPAR, AhR, nuclear receptors, p53, TCF/β- catenin, NF-κB, and many more.

AP-1

Tanshinone IIA | AP-1 transcription factor inhibitor

CAS:
568-72-9
Catalog Number:
10-2186
Activity:
AP-1 transcription factor inhibitor
Chemical Name:
1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10.11-dione
Molecular Weight:
294.35
Molecular Formula:
C19H18O3
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Andrographolide | Induces mitochondrial-mediated apoptosis

CAS:
5508-58-7
Catalog Number:
10-1173
Activity:
Induces mitochondrial-mediated apoptosis
Molecular Weight:
350.45
Molecular Formula:
C20H30O6
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 8 mg/ml).
Physical Properties:
Off-white solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Aryl hydrocarbon receptor

Laquinimod | Immunomodulator

CAS:
248281-84-7
Catalog Number:
10-4971
Activity:
Immunomodulator
Chemical Names:
5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide
Alternate Name:
ABR-215062
Molecular Weight:
356.81
Molecular Formula:
C19H17ClN2O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

CH-223191 | Arylhydrocarbon receptor antagonist

CAS:
301326-22-7
Catalog Number:
10-3089
Activity:
Arylhydrocarbon receptor antagonist
Chemical Name:
1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]-1H-pyrazole-5-carboxamide
Molecular Weight:
333.39
Molecular Formula:
C19H19N5O
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Cinnabarinic acid | Endogenous AhR ligand

CAS:
606-59-7
Catalog Number:
10-2883
Activity:
Endogenous AhR ligand
Chemical Name:
2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
Alternate Names:
Cinnabaric acid
Molecular Weight:
300.22
Molecular Formula:
C14H8N2O6
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 25 mg/ml).
Physical Properties:
Red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
Shipping Code:
RT

CREB

JQ1 (+) | BET Bromodomain inhibitor

CAS:
1268524-70-4
Catalog Number:
10-1584
Activity:
BET Bromodomain inhibitor
Chemical Name:
(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
Molecular Weight:
456.99
Molecular Formula:
C23H25ClN4O2S
Solubility:
Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 46 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT

HIF

Roxadustat | Proyl hydroxylase domain inhibitor / HIF stabilizer

CAS:
808118-40-3
Catalog Number:
10-4468
Activity:
Proyl hydroxylase domain inhibitor / HIF stabilizer
Chemical Name:
2-[(4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid
Alternate Name:
FG-4592
Molecular Weight:
352.35
Molecular Formula:
C19H16N2O5
Solubility:
Soluble in DMSO (up to at least 25 mg/ml).
Physical Properties:
Off-white or white solid
Purity:
99% by HPLC
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

YC-1 | Soluble guanylyl cyclase activator

CAS:
170632-47-0
Catalog Number:
10-1581
Activity:
Soluble guanylyl cyclase activator
Chemical Name:
3-(5′-Hydroxymethyl-2′-furyl)-1-benzylindazole
Alternate Name:
Lificiguat
Molecular Weight:
304.34
Molecular Formula:
C19H16N2O2
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml).
Physical Properties:
Pink solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

BAY 87-2243 | HIF-1 / Mitochondrial complex I inhibitor

CAS:
1227158-85-1
Catalog Number:
10-4910
Activity:
HIF-1 / Mitochondrial complex I inhibitor
Chemical Name:
5-[1-[[2-(4-Cyclopropylpiperazin-1-yl)pyridin-4-yl]methyl]-5-methylpyrazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole
Molecular Weight:
525.54
Molecular Formula:
C26H26F3N7O2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (10 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT

Myc

10074-G5 | c-Myc inhibitor

CAS:
413611-93-5
Catalog Number:
10-5627
Activity:
c-Myc inhibitor
Chemical Names:
7-Nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-4-amine
Molecular Weight:
332.32
Molecular Formula:
C18H12N4O3
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Orange solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

WP1066 | JAK2/STAT3 inhibitor

CAS:
857064-38-1
Catalog Number:
10-4831
Activity:
JAK2/STAT3 inhibitor
Chemical Name:
(E)-3-(6-Pyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide
Molecular Weight:
356.22
Molecular Formula:
C18H14BrN3O
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

THZ1 | Potent and selective CDK7 inhibitor

CAS:
1604810-83-4
Catalog Number:
10-4120
Activity:
Potent and selective CDK7 inhibitor
Chemical Name:
(E)-N-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
Molecular Weight:
566.05
Molecular Formula:
C31H28ClN7O2
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
Tan solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

NF-kB/IkB

CBL0137 | Inhibitor of the histone chaperone FACT

CBL0137 (1197996-80-7) is an anticancer agent that activates p53 and suppresses NF-kB via trapping of the FACT (facilitates chromatin transcription) complex, an important histone chaperone that mediates nucleosome

2E151 | Vaccine co-adjuvant

Vaccine adjuvants are materials that enhance the magnitude and duration of protective immune responses, typically via pattern recognition receptors (PRR).  2E151 (2416963-37-4) is a co-adjuvant that

Nrf2

Lipoic acid | Endogenous antioxidant and cofactor

alpha-Lipoic acid (1077-28-7) is an endogenous antioxidant.1,2 Treatment with alpha-lipoic acid increased hepatic nuclear Nrf2 levels, induced Nrf2-mediated gene transcription, and reversed age-related decline in hepatic

CBR-470-1 | NRF2 signaling activator

CBR-470-1 (2416095-06-0) is an activator of NRF2 signaling (EC50 ~ 1 µM cellular ARE-LUC assay).1 It inhibits phosphoglycerate kinase 1 leading to a build-up of methylglyoxal which inactivates

p53

SR1078 | ROR agonist

SR1078 (1246525-60-9) is an agonist of the orphan nuclear receptors RORα and RORγ.1 It attenuated intrapancreatic pathological changes in mouse models of chronic pancreatitis via restoration of the circadian

CBL0137 | Inhibitor of the histone chaperone FACT

CBL0137 (1197996-80-7) is an anticancer agent that activates p53 and suppresses NF-kB via trapping of the FACT (facilitates chromatin transcription) complex, an important histone chaperone that mediates nucleosome

STAT

WP1066 | JAK2/STAT3 inhibitor

CAS:
857064-38-1
Catalog Number:
10-4831
Activity:
JAK2/STAT3 inhibitor
Chemical Name:
(E)-3-(6-Pyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide
Molecular Weight:
356.22
Molecular Formula:
C18H14BrN3O
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Napabucasin | STAT3 inhibitor / Cancer cell stemness inhibitor

CAS:
83280-65-3
Catalog Number:
10-3442
Activity:
STAT3 inhibitor / Cancer cell stemness inhibitor
Chemical Name:
2-Acetylnsphtho[2,3-b]furan-4,9-dione
Alternate Names:
BBI608
Molecular Weight:
240.21
Molecular Formula:
C14H8O4
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Caerulomycin A | Blocks STAT1 signaling / Immunosuppressant

CAS:
21802-37-9
Catalog Number:
10-2897
Activity:
Blocks STAT1 signaling / Immunosuppressant
Chemical Name:
(2Z)-4-Methoxy-2-(nitrosomethylidene)-6-pyridin-2-yl-1H-pyridine
Molecular Weight:
229.23
Molecular Formula:
C12H11N3O2
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Other

Ceapin-A7 | ATF6α/UPR inhibitor

CAS:
2323027-38-7
Catalog Number:
10-3974
Activity:
ATF6α/UPR inhibitor
Chemical Names:
N-(1-{[2,4-bis(Trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-5-(furan-2-yl)-1,2-oxazole-3-carboxamide
Molecular Weight:
470.33
Molecular Formula:
C20H12F6N4O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

WP631 | SP-1 activated transcription inhibitor

CAS:

Not available

Catalog Number:
10-3497
Activity:
SP-1 activated transcription inhibitor
Chemical Names:

4-Methylbenzyl-N-bis[daunomycin], mesylate salt

Molecular Weight:
1349.38
Molecular Formula:
C62H64N2O20 ∙ 2CH3SO3H
Solubility:
Soluble in DMSO (up to 5 mg/ml)
Physical Properties:
Red solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des,)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT