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  • Focus Biomolecules supplier, chemical structure Caerulomycin A | Blocks STAT1 signaling / Immunosuppressant | CAS 21802-37-9
    Caerulomycin A (21802-37-9) chemically novel and potent immunosuppressive agent. Suppresses T cell activation and IFN7gamma; secretion in vitro and in vivo1. Caerulomycin A induces expansion of regulatory T cells by via...

  • Napabucasin | STAT3 inhibitor / Cancer cell stemness inhibitor
    Napabucasin (83280-65-3) inhibits gene transcription driven by STAT3. Inhibits cancer cell stemness gene expression and blocks spherogenesis of stemness-high cancer cells isolated from a variety of cancer types.1 Effective...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Niclosamide | STAT3 signaling inhibitor | CAS 50-65-7
    Niclosamide (50-65-7) reversibly inhibits mTORC1 signaling and stimulates autophagy1. Inhibits activation and nuclear translocation of STAT3 selectively over STAT1 and STAT5. Niclosamide inhibits transcription of STAT3...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Stattic | STAT3 inhibitor | CAS 19983-44-9
    Stattic (19983-44-9) is a STAT3 inhibitor that inhibits binding of tyrosine-phosphorylated peptides to STAT3 SH2 domain and inhibiting STAT3 activation, dimerization and nuclear translocation1. Displays selectivity over...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Tofacitinib | JAK inhibitor | CAS 477600-75-2
    Tofacitinib (477600-75-2) is a potent pan-JAK inhibitor, IC50s=1, 20 and 112 nM for JAK3, JAK2 and JAK1 respectively.1 Displays potent antiinflammatory2 and immunosuppressant3 activity. Promotes a white-to-brown metabolic...

  • WP1066 | JAK2/STAT3 inhibitor
    WP1066 (857064-38-1) is an inhibitor of the JAK2/STAT3 pathway as well as STAT5 and AKT.1,2,3 It downregulated Bcl-XL, Mcl-1, and c-myc while activating Bax and inducing apoptosis.1 Active against human malignant glioma...

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