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Biochemical Process ReagentsUbiquitin Proteasome Pathways

Ubiquitin Proteasome Pathways

Ubiquitin Proteasome Pathways (UPP) are important in a variety of cell processes. UPP products are invaluable for the study of defects in these processes which cause conditions such as cancer, inflammation and DNA damage.

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  • IU1

    A selective inhibitor of Usp14 

  • P5091

    a selective inhibitor of the ubiquitin-specific protease

  • PR-619

    A nonselective, reversible inhibitor of cysteine-reactive deubiquitinating enzymes

  • Spautin-1

    A specific and potent autophagy inhibitor

View All DUB Reagents

Ubiquitin Ligase

  • Heclin

    The first small molecule inhibitor of the HECT domain

  • SMER3

    A specific inhibitor if the ubiquitin E3 ligase 

  • Thalidomide

    Binds to the E3 ubiquitin ligase complex

View All Ubiquitin Ligase Reagents


  • Bortezomib

    A potent and selective proteasome inhibitor

  • Carfilozomib

    A potent and irreversible proteasome inhibitor

  • Lactacyctin

    A specific inhibitor of three proteolytic activities of the proteasome

  • MG-132

    A specific inhibitor of the 20S proteasome

View All Proteasome Reagents

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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