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  • b-AP15 | 1009817-63-3 | Structure | Supplier
    b-AP15 (1009817-63-3) abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of...

  • IU1 | 314245-33-5 | Structure | Supplier
    IU1 (314245-33-5) is a selective inhibitor of Usp14 (IC50<4 μM). Enhances proteasome activity and substrate proteolysis.1,2 Inhibits Dengue virus replication.3 In prion-infected CAD5 cells activation of the...

  • LDN-57444 | 668467-91-2 | Structure | Supplier
    LDN-57444 (668467-91-2) inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 μM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. LDN-57444 causes dramatic alterations...

  • ML-323 | USP-1/UAF-1 inhibitor
    ML-323 (1571424-83-5) is a potent and reversible USP1-UAF1 deubiquitinase complex inhibitor with excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases, IC50=76 nM in a ubiquitin-rhodamine...

  • P22077 | Selective USP7 inhibitor
    P22077 (1247819-59-5) is a selective (tested against 23 other DUBs) inhibitor of USP7 (IC50 = 8 µM) and the closely related USP47.1,2 It destabilizes claspin, a scaffolding protein involved in regulating Chk1 kinase, a...

  • P5091 | 882257-11-6 | Structure | Supplier
    P5091 (882257-11-6) is a selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM)1,2. Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance1. P5091 displays antiangiogenic...

  • PR-619 | 2645-32-1 | Structure | Supplier
    PR-619 (2645-32-1) is a nonselective, reversible inhibitor of cysteine-reactive deubiquitinating enzymes (DUBs; 5-20 μM)1. PR-619 is highly useful for preserving ubiquitinated proteins during cell lysis. DUBs become...

  • Spautin-1 | 1262888-28-7 | Structure | Supplier
    Spautin-1 (1262888-28-7) is a specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1...

  • TCID | DUB inhibitor
    TCID (30675-13-9) inhibits ubiquitin C-terminal hydrolase L3 (UCH-L3). IC50=0.6 μM, 125-fold selective over UCH-L1, IC50=75 μM. Cell permeable. References/Citations1) Love et al. (2007), Mechanisms, biology and...

  • WP-1130 | 856243-80-6 | Structure | Supplier
    WP-1130 (856243-80-6) is a novel DUB inhibitor directly inhibiting USP9x, USP5, USP14 and UCH37 inducing rapid accumulation of polyubiquitinated proteins. Triggers tumor cell apoptosis.1 Blocks Jak2 signaling via Jak2...

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