DUBS

Showing all 10 results

  • Apoptosis

    b-AP15 | DUB inhibitor

    Rated 0 out of 5
    b-AP15 (1009817-63-3) abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5)...
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  • DUBS

    IU1 | Usp-14 inhibitor

    Rated 0 out of 5
    IU1 (314245-33-5) is a selective inhibitor of Usp14 (IC50<4 μM). Enhances proteasome activity and substrate proteolysis.1,2 Inhibits Dengue viru...
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  • Apoptosis

    LDN-57444 | DUB inhibitor

    Rated 0 out of 5
    LDN-57444 (668467-91-2) inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 μM). Decreases proteasome activity and increases levels of ubiquit...
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  • Cellular Stress

    ML323 | USP-1/UAF-1 inhibitor

    Rated 0 out of 5
    ML323 (1571424-83-5) is a potent and reversible USP1-UAF1 deubiquitinase complex inhibitor with excellent selectivity against human DUBs, deSUMOyla...
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  • Cancer

    P22077 | Selective USP7 inhibitor

    Rated 0 out of 5
    P22077 (1247819-59-5) is a selective (tested against 23 other DUBs) inhibitor of USP7 (IC50 = 8 µM) and the closely related USP47.1,2 It destabiliz...
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  • Angiogenesis

    P5091 | DUB USP7 inhibitor

    Rated 0 out of 5
    P5091 (882257-11-6) is a selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM)1,2. Induces apoptosis in multiple myeloma cells...
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  • Cancer

    PR-619 | DUB inhibitor

    Rated 0 out of 5
    PR-619 (2645-32-1) is a nonselective, reversible inhibitor of cysteine-reactive deubiquitinating enzymes (DUBs; 5-20 μM)1. PR-619 is highly useful ...
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  • Autophagy

    Spautin-1 | Inhibits autophagy by inhibiting USP 10 and 13

    Rated 0 out of 5
    Spautin-1 (1262888-28-7) is a specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiti...
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  • DUBS

    TCID | DUB inhibitor

    Rated 0 out of 5
    TCID (30675-13-9) inhibits ubiquitin C-terminal hydrolase L3 (UCH-L3). IC50=0.6 μM, 125-fold selective over UCH-L1, IC50=75 μM. Cell permeable. ...
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  • Apoptosis

    WP1130 | DUB inhibitor

    Rated 0 out of 5
    WP1130 (856243-80-6) is a novel DUB inhibitor directly inhibiting USP9x, USP5, USP14 and UCH37 inducing rapid accumulation of polyubiquitinated pro...
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