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E3 Ubiquitin Ligase

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  • Focus Biomolecules supplier, structure of Heclin | HECT domain containing E3 ubiquitin ligase inhibitor | CAS 890605-54-6
    Heclin (890605-54-6) is the first small molecule inhibitor of the HECT domain-containing E3 ubiquitin ligases. Heclin (HECT ligase inhibitor) inhibits several HECT ligases in cultured cells, IC50s = 6.8, 6.3 and 6.9 μM...

  • Lenalidomide | Immunomodulator
    Lenalidomide (191732-72-6) is a thalidomide analog which, like thalidomide1, binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2...

  • NAcM-OPT | Structure | Supplier
    NAcM-OPT is a potent and selective NEDD8 ligation inhibitor, IC50=80 nM (in vitro).1  It inhibits the N-terminal acetyl-dependent interaction between the E2 conjugating enzyme UBE2M/UBC12 and DCN1, a subunit of a...

  • PRT4165 | 31083-55-3 | Structure | Supplier
    PRT-4165 (31083-55-3) is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit. Blocks...

  • Focus Biomolecules supplier, chemical structure of SMER3 | E3 Ubiquitin ligase inhibitor | CAS 67200-34-4
    SMER3 ( 67200-34-4; Small Molecule Enhancer of Rapamycin 3) is a specific inhibitor if the ubiquitin E3 ligase SCFMET30 both in vitro and in vivo. References/Citations1) Aghajanyy et al. (2010), Chemical genetics of TOR...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of TAME | Ubiquitin ligase inhibitor | CAS 1784-03-8
    TAME (1784-03-8) binds to the ubiquitin ligase anaphase-promoting complex (APC) preventing its activation by Cdc20 and Cdh1 and resulting in mitotic arrest.1,2 References/Citations1) Zeng et al. (2010) Pharmacologic...

  • Focus Biomolecules cell signaling reagent supplier, structure of Thalidomide | E3 UB ligase inhibitor | CAS 50-35-1
    Thalidomide (50-35-1) binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A, and inhibits the ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Handle with caution,...

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