Thalidomide (50-35-1) binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A, and inhibits the ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Handle with caution, compound is teratogenic.
References/Citations:
1) Ito et al. (2010), Identification of a primary target of thalidomide teratogenicity; Science, 327 1345
2) Weglicki et al. (1993), Inhibition of tumor necrosis factor-alpha by thalidomide in magnesium deficiency; Mol. Cell. Biochem., 129 195
3) D’Amato et al. (1994), Thalidomide is an inhibitor of angiogenesis ; Proc. Natl. Acad. Sci. USA, 91 4082
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