Thalidomide | E3 UB ligase inhibitor

Thalidomide (50-35-1) binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A, and inhibits the ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Handle with caution, compound is teratogenic.

References/Citations
1) Ito et al. (2010), Identification of a primary target of thalidomide teratogenicity; Science, 327 1345
2) Weglicki et al. (1993), Inhibition of tumor necrosis factor-alpha by thalidomide in magnesium deficiency; Mol. Cell. Biochem., 129 195
3) D’Amato et al. (1994), Thalidomide is an inhibitor of angiogenesis ; Proc. Natl. Acad. Sci. USA, 91 4082

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
size :

100 mg, 500 mg

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CAS:
50-35-1
Catalog Number:
10-1115
Activity:
E3 UB ligase inhibitor
Chemical Name:
N-(2,6-Dioxo-3-piperidinyl)phthalimide, racemic
Molecular Weight:
258.25
Molecular Formula:
C13H10N2O4
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Thalidomide | E3 UB ligase inhibitor

$50.00$200.00

CAS:
50-35-1
Catalog Number:
10-1115
Activity:
E3 UB ligase inhibitor
Chemical Name:
N-(2,6-Dioxo-3-piperidinyl)phthalimide, racemic
Molecular Weight:
258.25
Molecular Formula:
C13H10N2O4
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
  • 100 mg
  • 500 mg
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