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Ubiquitin-like modifiers

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  • Focus Biomolecules cell signaling tech supplier, structure of MLN4924 | NEDD8 activating enzyme inhibitor | CAS 905579-51-3
    MLN4924 (905579-51-3) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor.1 It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. Suppresses the growth of...

  • Focus Biomolecules cell signaling supplier, chemical structure of NAcM-OPT | NEDD8 ligation inhibitor | CAS 2089293-61-6
    NAcM-OPT is a potent and selective NEDD8 ligation inhibitor, IC50=80 nM (in vitro).1  It inhibits the N-terminal acetyl-dependent interaction between the E2 conjugating enzyme UBE2M/UBC12 and DCN1, a subunit of a...