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Product Details

Vandetanib | VEGFRK inhibitor

Vandetanib (443913-73-3) is a potent and selective inhibitor of  VEGFR2, ( KDR IC50 = 40 nM). Also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC50 = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC50 = 500 nM) but shows selectivity against a panel of other tyrosine and serine-threonine kinases. Inhibits colony formation in seven cancer cell lines.2 Vandetanib also displays anti-angiogenesis activity.3

References/Citations

1) Wedge et al. (2002), ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis and tumor growth following oral administration;  Cancer Res., 62 4645
2) Ciardiello et al. (2003), Antitunmor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase;  Clin. Cancer Res., 9 1546
3) Herbst et al. (2007), Vandetanib (ZD6474): an orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis;  Expert Opin. Investig. Drugs, 16 239

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Vandetanib | VEGFRK inhibitor | CAS 443913-73-3

Catalog#  10-2185

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CAS:
443913-73-3
Catalog Number:
10-2185
Activity:
VEGFRK inhibitor
Chemical Name:
4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-yl)methoxy]quinazoline
Alternate Names:
ZD6474
Molecular Weight:
475.35
Molecular Formula:
C22H24BrFN4O2
Solubility:
Soluble in DMSO (up to 30 mg/ml or in Ethanol (up to 10 mg/ml with warming)
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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