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Xestospongin C | Inhibitor of IP3-mediated Ca2+ release

Xestospongin C (88903-69-9) is a potent and reversible inhibitor of IP3-mediated Ca2+ release, IC50 = 358 nM.1 Experiments with guinea-pig ileum permeabilized with alpha toxin revealed that Xestospongin C inhibits the IP3 receptor but not the ryanodine receptor in SR membranes. In intact smooth muscle cells it inhibits voltage-dependent Ca2+ and K+ currents at a concentration range similar to that at which it inhibits the IP3 receptor. Xestospongin C is a useful tool for probing the involvement of IP3 receptors in cellular signaling.3 Cell permeable.

References/Citations

1) Wilcox et al. (1998), New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor;  Trends Pharmacol. Sci., 19 467
2) Ozaki et al. (2002), Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle;  Br. J. Pharmacol., 137 1207
3) Kandasamy et al. (2013), Lipopolysaccharide induces endoplasmic store Ca2+-dependent inflammatory responses in lung microvessels;  PLoS One, 8 e63465

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Focus Biomolecules supplier, chemical structure of Xestospongin C | Inhibitor of IP3-mediated Ca2+ release | CAS 88903-69-9

Catalog#  10-1207-0010

$75.00
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CAS:
88903-69-9
Catalog Number:
10-1207
Activity:
Inhibits IP3-mediated Ca2+ release
Molecular Weight:
446.71
Molecular Formula:
C28H50N2O2
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
Lyophilized solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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