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Product Details

TOFA | Acyl-CoA carboxylase inhibitor

TOFA (54857-86-2) interferes with fatty acid synthase via inhibition of acetyl Co-A carboxylase (ACC1)1. Induces apoptosis in a variety of tumor cell lines2,3. Stimulates neurite outgrowth and neuronal differentiation in rat pheochromocytoma cells4. TOFA impairs glucose-stimulated insulin secretion after chronic treatment5.

References/Citations
1) Halvorson et al. (1984), Inhibition of fatty acid synthesis in isolated adipocytes by 5-tetradecyloxy)-2-furoic acid; Lipids, 19 851
2) Guseva et al. (2011), TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status; Cancer Biol. Ther., 12 80
3) Zhou et al. (2003), Fatty acid synthesis inhibition triggers apoptosis during S phase in human cancer cells; Cancer Res., 63 7330
4) Schmidt et al. (1999), Transcription control and neuronal differentiation by agents that activate the LXR nuclear receptor family; Mol. Cell. Endocrinol., 155 51
5) Ronnebaum et al. (2008), Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism; J. Biol. Chem., 283 14248

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TOFA | 54857-86-2 | Structure | Supplier

Catalog#  10-1464

$50.00
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CAS:
54857-86-2
Catalog Number:
10-1464
Activity:
Acyl-CoA carboxylase inhibitor
Alternate Names:
RMI-14514
Chemical Name:
5-(Tetradecyloxy)-2-furoic acid
Molecular Weight:
324.47
Molecular Formula:
C19H32O4
Solubility:
Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 9 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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