Cellular Senescence
Cellular senescence is a state of permanent cell cycle arrest resulting in changes to cell morphology, physiology, gene expression, and chromatin organization. Cells derived from normal tissues undergo senescence after a certain number of divisions in culture, whereas tumor cells often do not. It also occurs during aging, and in diseases such as Alzheimer’s and diabetes. It can be induced by numerous stresses, such as telomere shortening, DNA damage, and oxidative stress.
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ABT-263 | Bcl-2 family inhibitor; Senolytic agent
From $60.00CAS:923564-51-6Catalog Number:10-3141Activity:Bcl-2 family inhibitor; Senolytic agentChemical Name:4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)- 3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-benzamideAlternate Name:NavitoclaxMolecular Weight:974.61Molecular Formula:C47H55ClF3N5O6S3Solubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:White solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT -
ABT-737 | Senolytic Bcl2 inhibitor
From $80.00CAS:852808-04-9Catalog Number:10-3661Activity:Senolytic Bcl inhibitorChemical Names:4-[4-[(4′-Chloro[1,1′-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-benzamideMolecular Weight:813.43Molecular Formula:C42H45ClN6O5S2Solubility:Soluble in DMSO (5 mg/ml)Physical Properties:Yellow solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Cycloastragenol | Telomerase activator/Senolytic agent
From $50.00Cycloastragenol (84605-18-5) is a novel naturally occurring terpenoid found in Astragalus which was shown to be a telomerase activator. In CD8+ T lymphocytes from HIV-infected donors […]
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Dasatinib | Src and Bcr/Abl inhibitor
From $50.00CAS:302962-49-8Catalog Number:10-2126Activity:Src and Bcr/Abl inhibitorAlternate Names:BMS-354825Chemical Name:N-(2-Chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamideMolecular Weight:488.01Molecular Formula:C22H26ClN7O2SSolubility:Soluble in DMSO (up to 200 mg/ml).Physical Properties:White or off-white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.Shipping Code:RT -
JPH203 | LAT1 inhibitor
From $95.00CAS:1597402-27-1Catalog Number:10-4464Activity:LAT1 inhibitorChemical Names:(2S)-2-Amino-3-[4-[(5-amino-2-phenyl-1,3-benzoxazol-7-yl)methoxy]-3,5-dichlorophenyl]propanoic acid dihydrochlorideAlternate Name:KYT-0353; NanvuralantMolecular Weight:545.24Molecular Formula:C23H19Cl2N3O4·2HClSolubility:Soluble in DMSO (>25 mg/ml)Physical Properties:Pale orange/yellow solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
L-Cycloserine | Serine palmitoyltransferase inhibitor
From $50.00L-Cycloserine (339-72-0) down-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase).1 The L isomer was shown to be 100-fold more potent than the D isomer at […]
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