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  • Dihydrosphingosine | PKC inhibitor, Sphingosine precursor
    Dihydrosphingosine (764-22-7) is a biosynthetic precursor of sphingosine. Inhibitor of protein kinase C1 and phospholipases A2 and D2. References/Citations1) Merrill et al. (1989), Structural requirements for long-chain...

  • Enzastaurin | PKC inhibitor
    Enzastaurin (170364-57-5) is a potent and selective PKCβ inhibitor.  IC50 = 6, 39, 83 and 110 nM, for PKCβ, PKCα, PKCγ and PKCε respectively.1 Induces apoptosis in multiple myeloma cell...

  • GF-109203X | 133052-90-1 | Structure | Supplier
    GF-109203X (133052-90-1) is a potent and selective protein kinase C inhibitor (IC50 = 10 nM; cAMP-dependent protein kinase IC50 = 2 μM and phosphorylase kinase IC50 = 0.7 μM). Inactive against the tyrosine kinases...

  • Go-6983 | PKC inhibitor
    Go-6983 (133053-19-7) potent and pan-specific, ATP-competitive protein kinase C inhibitor. PKC isotype IC50s= 7, 7, 6, 10 and 60 nM for PKC α, β, γ, δ, ζ respectively.1 Suppresses stress induced...

  • Hypericin | Protein kinase C inhibitor
    Hypericin (548-04-9) is a natural product found in St. John's Wort (Hypericum perforatum). A multifunctional agent that has been reported to be antidepressive, antineoplastic, antitumor and antiviral. Inhibitory effects have...

  • Indolactam V | PKC activator; Stem cell inducer
    Indolactam V (-) (90365-57-4) is a PKC activator acting at the phorbol ester binding site.1,2 Directs differentiation of human and mouse ESCs to pancreatic cells.3   May be used, along with other agents, to...

  • NPC-15437 | 141774-20-1 | Structure | supplier
    NPC-15437 (141774-20-1) is a potent and selective inhibitor of protein kinase inhibitor C which binds to the regulatory domain (IC50 = 19 μM). Important tool for assessing the role of PKC in various signaling pathways...

  • Okadaic acid | Protein phosphatase inhibitor
    Okadaic acid (78111-17-8) is a naturally occurring polyether marine toxin. Potent and selective inhibitor of protein phosphatases inhibiting PP2A completely at 1 nM and PP1 at higher concentrations, while PP2C is not...

  • Phorbol 12-myristate-13-acetate | PKC activator
    Phorbol 12-myristate-13-acetate (16561-29-8) activates protein kinase C (10-100 ng/ml)1. May display PKC-independent effects in various cell types2. Warning: Phorbol 12-myristate-13-acetate is a skin irritant. Avoid contact...

  • Prostratin | Promotes neuro-regeneration
    Prostratin (60857-08-1) is a terpenoid, non-tumorigenic PKC activator isolated from Pimelia prostrate.1,2 Induces differentiation of human myeloid leukemia cells and potentiates differentiation by chemotherapeutic agents.3...

  • Sphingosine | PKC inhibitor
    Sphingosine (123-78-4) is an inhibitor of protein kinase C (IC50 = 1-3 μM).1 It is abundant in cell membranes and is an important mediator in various biochemical pathways.2-4 References/Citations1) Merrill et al., (1989)...

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