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Mirin | Mre11-Rad50-Nbs1 inhibitor

Mirin (299953-00-7) is an inhibitor of the Mre11-Rad50-Nbs1(MRN) complex (IC50 = 12 μM for inhibition of ATM activity), part of the MRN-ATM(ataxia-telangiectasia mutated) pathway, an essential pathway for sensing and signaling from DNA double-strand breaks. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells.

References/Citations
1) Dupre et al. (2008), A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex; Nat. Chem. Biol., 4 119

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Focus Biomolecules cell signaling reagent supplier, structure of Mirin | Mre11-Rad50-Nbs1 inhibitor | CAS 299953-00-7

Catalog#  10-1069

$50.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
299953-00-7
Catalog Number:
10-1069
Activity:
Mre11-Rad50-Nbs1 inhibitor
Chemical Name:
5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one
Molecular Weight:
220.25
Molecular Formula:
C10H8N2O2S
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Protect from moisture. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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