my account
Login
  Loading... Please wait...

Product Details

Kynurenine (L) | Endogenous Ahr agonist

Kynurenine (2922-83-0) is a tryptophan catabolite1. Endogenous tumor-promoting ligand of the human aryl hydrocarbon receptor (AhR). Constitutively generated by human tumor cells via the action of the tryptophan degrading enzyme, tryptophan-2,3-dioxygenase (TDO). Kynurenine suppresses antitumor immune responses and promotes tumor cell survival and motility2.

References/Citations
1) Ibana et al. (2011), Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlaydia trachomatis persistence in human epithelial cells; Infect. Immun., 79 4425
2) Opitz et al. (2011), An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor; Nature, 478 197

swipe
Image 1

Catalog#  10-2666

$38.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
2922-83-0
Catalog Number:
10-2666
Activity:
Endogenous Ahr agonist
Chemical Name:
β-Anthraniloyl-L-alanine; L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
Molecular Weight:
208.22
Molecular Formula:
C10H12N2O3
Solubility:
Soluble in DMSO (up to 2 mg/ml) or in Water (up to 2 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Share Focus

Connect with Focus

Click the button below to add the Kynurenine (L) | Endogenous Ahr agonist to your wish list.