Inflammasome

  • Belnacasan | ICE/caspase-1 inhibitor

    CAS:
    273404-37-8
    Catalog Number:
    10-4399
    Activity:
    ICE/caspase-1 inhibitor
    Chemical Names:
    (S)-1-((S)-2-(4-Amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide; VX-765
    Molecular Weight:
    508.99
    Molecular Formula:
    C24H33ClN4O6
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white to white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $45.00
  • Ezetimibe | Cholesterol absorption inhibitor

    CAS:
    163222-33-1
    Catalog Number:
    10-2027
    Activity:
    Cholesterol absorption inhibitor
    Chemical Name:
    (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidine-2-one
    Alternate Names:
    SCH 58235; Ezetrol
    Molecular Weight:
    409.43
    Molecular Formula:
    C24H21F2NO3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml)
    Physical Properties:
    White or off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $55.00
  • L6H21 | MD-2/TLR4 interaction inhibitor

    CAS:
    24533-47-9
    Catalog Number:
    10-5574
    Activity:
    MD-2/TLR4 interaction inhibitor
    Chemical Names:
    (2E)-3-(2,3-Dimethoxyphenyl)-1-(4-methoxyphenyl)-2-propen-1-one; (E)-2,3-dimethoxy-4′-methoxychalcone
    Molecular Weight:
    298.34
    Molecular Formula:
    C18H18O4
    Solubility:
    Soluble in DMSO (60 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $55.00
  • Lamivudine | Reverse transcriptase inhibitor

    CAS:
    134678-17-4
    Catalog Number:
    10-2028
    Activity:
    Reverse transcriptase inhibitor
    Chemical Names:
    4-Amino-1-[(2R,5S)-2-(hydroxymethyl)1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
    Alternate Name:
    (-)-BCH-189; 3TC
    Molecular Weight:
    229.25
    Molecular Formula:
    C8H11N3O3S
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
    From $45.00
  • MCC-950 | NLRP3 inflammasome inhibitor

    CAS:
    210826-40-7
    Catalog Number:
    10-2990
    Activity:
    NLRP3 inflammasome inhibitor
    Chemical Name:
    N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt
    Alternate Names:
    CRID3; CP-456773 sodium salt
    Molecular Weight:
    426.46
    Molecular Formula:
    C20H23N2O5S
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Water (up to 30 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
    From $56.00
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