Focused on
Life Science Reagents

Focus Biomolecules brings innovative cellular signaling tools to the life
sciences research community and provides superior customer and
technical support.

Biochemical Targets

Physiological Processes and Diseases

Featured Products:

Resiniferatoxin | TRPV1 agonist

Resiniferatoxin (57444-62-9) is back in stock at the best price on the web. Bulk available!

YM-254890 | Gq inhibitor

YM-254890 (568580-02-9) is a novel Gαq/11 inhibitor.1 U46619-induced platelet aggregation is inhibited but phorbol ester- or ionophore-induced aggregation is not2 (IC50 = 0.1-0.2 μM)1. It blocks Pasteurella multocida toxin-mediated activation of Gαq.3 A highly useful new tool for studying Gαq/11-coupled receptor signaling and resulting cellular events.4

7-Cl-O-Nec1 | RIP1 inhibitor

7-Cl-O-Nec1 (852391-15-2) is a necrostatin-1 (Cat.# 10-1162) analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4 7-Cl-O-Nec1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50 = 210 nM vs. EC50 = 490 nM), no non-specific cytotoxicity at high concentrations (100 μM) and reasonable pharmacokinetic characteristics when used in mice.2 7-Cl-O-Nec1 is recommended for cellular and in vivo use over Necrostatin-1.5

NEW PRODUCTS

KNK437

Inhibits HSP70 expression

L6H21

MDL/TLR4 interaction inhibitor

Sulfopin

Covalent Pin1 inhibitor

CUSTOM SYNTHESIS

The Focus Biomolecules custom synthesis team is highly experienced in the production of a wide array of biologically active small molecules. Submit your synthesis requests for a rapid, confidential, and cost effective quotation.

CHEMICAL LIBRARIES

The scientists at Focus Biomolecules are at the forefront in the development of known bioactive chemical libraries. Let our unique and intelligently designed libraries make a difference in your research.

Resiniferatoxin for pain research – in stock now

The 2021 Nobel Prize in Medicine was awarded to David Julius and Ardem Patapoutian because of their research on TRPV1 (Transient Receptor Potential...

Update on the Latest Anti-SARS-CoV-2 Molecules

The emergence of SARS-CoV-2 has precipitated an unprecedented effort by the scientific community to find and develop potential therapeutics and...

REV-ERB agonists and Cancer

Researchers at the Salk Institute, the University of California, and the University of Texas have identified a potential new class of cancer...

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

United Kingdom

Tebu-bio UK & Ireland
Unit 7 - Flag Business Exchange
Vicarage Farm Road
Peterborough
Cambs PE1 5TX
England

Phone: +44 (0)1733 421880
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2B Scientific
Cherwell Innovation Centre
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Upper Heyford
OX25 5HD
UK

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Germany

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Berliner Str. 255
D-63067 Offenbach

Tel: (069) 801013-0
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BIOZOL Diagnostica Vertrieb GmbH
Obere Hauptstrasse 10b
85386 Eching

Tel: +498937996666
E-mail: info@biozol.de
www.biozol.de

Biotrend Germany
Wilhelm-Mauser-Str. 41-43
50827 Köln
Tel: +49 221 9498320
Fax: +49 221 9498325
Email:  info @biotrend.com
www.biotrend.com

Portugal

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Fax: (069) 801013-20
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Switzerland

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CH-6006 Luzern
Switzerland

Phone: +41 (0)41 420 9636
Fax: +41 (0)41 420 9656
E-mail: lucerna-chem@lucerna-chem.ch
www.lucerna-chem.ch

Anawa
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CH-8602 Wangen
Switzerland

Phone: +41 (0)44 805 76 81
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E-mail: contactus@anawa.ch
www.anawa.ch

Belgium

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Alexander Franckstraat 196
B-2530 Boechout

Phone: 03/ 454 00 66
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Austria

Biomedica Medizinprodukte gmbH & Co KG
Divischgasse 4
1210 Vienna
Austria

Phone: +43 1 291 07 0
Fax: +43 1 290 14 29
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www.bmgrp.at

Biotrend Austria
Sternwartwatrasse 76
A-1180 Wien
Austria

Phone: +43 7201 15577
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Bulgaria

Biomedica Bulgaria Ltd.
2E "Akad. Ivan E. Geshov" blvd.
Business center "Serdika" build. 2, floor 2, office 203
Sofia 1330
Bulgaria

Phone: +359 2 447 2833
Fax: +359 2 447 2831
Email: office@bmgrp.bg
www.bmgrp.bg

Czech Republic

Biomedica CS, s.r.o.
Sokolovska 100/94, Meteor B
186 00 Praha 8 - Karlin
Czech Republic

Phone: +420 2 839 33 605
Fax: +420 2 839 32 507
Email: office@bmgrp.cz
www.bmgrp.cz

Macedonia

Biomedica dijagnostika Ltd.
Ul. Ilindenska br. 103 lokal 2 and 3
1000 Skopje
Macedonia

Phone: +389 232 22 404
Fax: +389 232 22 404
Email: office@bmgrp.mk
www.bmgrp.mk

Romania

Biomedica Medizinprodukte Romania SRL
Strada Siriului nr. 42-46, Et.2, Sector 1
014354 Bucharest
Romania

Phone: +40 37 276 68 44
Fax: +40 21 232 22 04
Email: office@bmgrp.ro
www.bmgrp.ro

France

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39 Rue de Houdan - BP 15
78612 Le Perray-en-Yvelines Cedex

Phone: 01 30 46 39 00
Fax: 01 30 46 39 11
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CliniSciences France
74 Rue des Suisses
92000 Nanterre

Phone: +33 9 77 40 09 09
Fax: +33 9 77 40 10 11
info@clinisciences.com
www.clinisciences.com

Spain

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ES-08011 Barcelona

Phone: 93 306 34 10
Fax: 93 306 34 99
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Italy

DBA Italia
Via Umbria, 10
20090 Segrate (Milan)
Italy

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Fax: +39 02 26923535
E-mail: info@dbaitalia.it
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Tebu-bio Italy
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I-20013 Magenta MI

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Clinisciences Italy
Via Maremmana Inferiore 378
00012 Guidonia Montecelio (Roma)

Phone: +39 06 94 80 56 71
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Italia@clinisciences.com
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Denmark

Tebu-bio Nordic Countries

CAT Science Park
Universitetsparken 7
4000 Roskilde
Denmark

Phone: +45 46 74 02 54
Fax: +45 46 74 02 53
www.tebu-bio.com


CliniSciences Denmark

Herlev Hovedgade 195
2730 Herlev

Phone: +45 89 888 349
Fax: +45 89 884 064
danmark@clinisciences.com
www.clinisciences.com

Sweden

Tebu-bio Netherlands  
Bevelandseweg 80
NL-1703 AX Heerhugowaard

Phone: 072-572 21 00
Fax: 072-572 21 33
www.tebu-bio.com

Finland

Tebu-bio Netherlands  
Bevelandseweg 80
NL-1703 AX Heerhugowaard

Phone: 072-572 21 00
Fax: 072-572 21 33
www.tebu-bio.com

Netherlands

Tebu-bio Netherlands  
Bevelandseweg 80
NL-1703 AX Heerhugowaard

Phone: 072-572 21 00
Fax: 072-572 21 33
www.tebu-bio.com

Bosnia-Herzegovina

Biomedica d.o.o
Dr. Silve Rizvanbegovic bb
71210 Ilidza, Sarajevo
Bosnia and Herzegovina

Phone: +387 33 262 725
Fax: 387 33 262 726
Email: office@bmgrp.ba
www.bmgrp.ba

Croatia

Biomedica Dijagnostika d.o.o.
Strojarska 20/X
10000 Zagreb
Croatia

Phone: +385 1 888 5727
Fax: +385 1 888 5728
Email: office@bmgrp.hr
www.bmgrp.hr

Hungary

Biomedica Hungaria Kft.
Ganz u. 16
1027 Budapest
Hungary

Phone: +361 225 38 50
Fax: +361 201 26 84
Email: office@bmgrp.hu
www.bmgrp.hu

Poland

Biomedica Poland sp. z.o.o.
Ul. Raszynska 13
05-500 Piaseczno
Poland

Phone: +48 22 737 5996
Fax: +48 22 737 5994
Email: office@bmgrp.pl
www.bmgrp.pl

Serbia

Biomedica MP d.o.o.  
Lazara Mamuzica 26a
11186 Zemun
Serbia

Phone: +381 11 630 1882
Fax: +381 11 630 1883
Email: office@bmgrp.rs
www.bmgrp.rs

Slovenia

Biomedica M.B. d.o.o.  
Slokanova 12
2000 Maribor
Slovenia

Phone: +386 2 471 63 01
Fax: +386 2 471 63 04
Email: office@bmgrp.si
www.bmgrp.si

Slovakia

Biomedica Slovakia s.r.o.
Drobneho 27
84101 Bratislava
Slovakia

Phone: +421 2 693 099 01
Fax: +421 2 693 099 08
Email: office@bmgrp.sk
www.bmgrp.sk

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