Focused on
Life Science Reagents

Focus Biomolecules brings innovative cellular signaling tools to the life
sciences research community and provides superior customer and
technical support.

Biochemical Targets

Physiological Processes and Diseases

Featured Products:

Herboxidiene | Spliceosome inhibitor

Herboxidiene (142861-00-5) is a novel polyketide fermentation product produced by Streptomyces chromofuscus, originally discovered by screening for herbicidal activity. Potent and selective inhibitor of spliceosome subunit SF3b.2 Specifically targets SAP155, a subunit of SF3b responsible for pre-mRNA splicing.3 Displays anti-angiogenic activity via down-regulation of VEGFR-2 and HIF-1α.4 Spliceosome inhibitors have attracted enormous attention due to their potential use in cancer treatment.5

YM-254890 | Gq inhibitor

YM-254890 (568580-02-9) is a novel Gαq/11 inhibitor.1 U46619-induced platelet aggregation is inhibited but phorbol ester- or ionophore-induced aggregation is not2 (IC50 = 0.1-0.2 μM)1. It blocks Pasteurella multocida toxin-mediated activation of Gαq.3 A highly useful new tool for studying Gαq/11-coupled receptor signaling and resulting cellular events.4

7-Cl-O-Nec1 | RIP1 inhibitor

7-Cl-O-Nec1 (852391-15-2) is a necrostatin-1 (Cat.# 10-1162) analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4 7-Cl-O-Nec1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50 = 210 nM vs. EC50 = 490 nM), no non-specific cytotoxicity at high concentrations (100 μM) and reasonable pharmacokinetic characteristics when used in mice.2 7-Cl-O-Nec1 is recommended for cellular and in vivo use over Necrostatin-1.5

NEW PRODUCTS

Methoprene Acid

Selective RXR agonist

ML-335

Trek-1,2 activator

NOTUMib-1

NOTUM inhibitor, restores Wnt signaling

CUSTOM SYNTHESIS

The Focus Biomolecules custom synthesis team is highly experienced in the production of a wide array of biologically active small molecules. Submit your synthesis requests for a rapid, confidential, and cost effective quotation.

CHEMICAL LIBRARIES

The scientists at Focus Biomolecules are at the forefront in the development of known bioactive chemical libraries. Let our unique and intelligently designed libraries make a difference in your research.

Update on the Latest Anti-SARS-CoV-2 Molecules

The emergence of SARS-CoV-2 has precipitated an unprecedented effort by the scientific community to find and develop potential therapeutics and...

REV-ERB agonists and Cancer

Researchers at the Salk Institute, the University of California, and the University of Texas have identified a potential new class of cancer...

SHP099 targets ALK inhibitor resistant cancer

Multiple cellular pathways can lead to acquired resistance to ALK inhibitors.  A common pathway is activation of alternate kinase pathways,...

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