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Life Science Reagents

YM-254890 (568580-02-9) is a novel Gα_q/11 inhibitor.¹ U46619-induced platelet aggregation is inhibited but phorbol ester- or ionophore-induced aggregation is not² (IC₅₀ = 0.1-0.2 μM)¹. It blocks Pasteurella multocida toxin-mediated activation of Gα_q.³ A highly useful new tool for studying Gα_q/11-coupled receptor signaling and resulting cellular events.⁴

7-Cl-O-Nec1 (852391-15-2) is a necrostatin-1 (Cat.# 10-1162) analogue with superior potency (IC₅₀ = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.^1,2 7-Cl-O-Nec1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).^3,4 7-Cl-O-Nec1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC₅₀ = 210 nM vs. EC₅₀ = 490 nM), no non-specific cytotoxicity at high concentrations (100 μM) and reasonable pharmacokinetic characteristics when used in mice.² 7-Cl-O-Nec1 is recommended for cellular and in vivo use over Necrostatin-1.⁵