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Synaptamide | Endogenous agonist at GPR110

Synaptamide (162758-94-3) is an anandamide-like lipid mediator produced from DHA in the brain. Stimulates neurite growth, synaptogenesis and glutamatergic synaptic activity in developing hippocampal neurons at 10-100 nM.1 Potently induces neuronal differentiation of neural stem cells.2 Promotes growth of cortical axons vial modulation of hedgehog signaling.3 Binds to and activates orphan receptor GPR110, stimulating cAMP production at low nM concentrations.4 Reduces LPS-induced TNFα production in cultured microglia cells and ameliorates LPS-induced neuroinflammation in a mouse model.5

References/Citations

1) Kim and Spector (2013), Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function; Prostaglandins Leukot. Essent. Fatty Acids , 88 121
2) Rashid et al. (2013), N-Docosahexaenoylethanolamide is a potent neurogenic factor for neural stem cell differentiation; J. Neurochem., 125 869
3) Kharebava et al. (2015), N-docosahexaenoylethanolamine regulates Hedgehog signaling and promotes growth of cortical axons; Biol. Open., 4 1660
4) Lee et al. (2016), Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function; Nat. Commun., 7 13123
5) Park et al. (2016), N-docosahexaenoylethanolamine ameliorates LPS-induced neuroinflammation via cAMP/PKA-dependent signaling; J. Neuroinflammation, 13 284

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Synaptamide | 162758-94-3 |Structure | Supplier

Catalog#  10-1194-0005

$30.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
162758-94-3
Catalog Number:
10-1194
Activity:
Endogenous agonist at GPR110
Chemical Name:
N-Docosahexaenoylethanolamide
Alternate Names:
DHA-ethanolamide
Molecular Weight:
371.56
Molecular Formula:
C24H37NO2
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
Colorless to yellow oil
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-80°C, protect from exposure to air.
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored under inert gas at -80°C for up to 3 months.
Shipping Code:
Dry Ice
FeaturedDescription:
Stimulates neurite growth, synaptogenesis and glutamatergic synaptic activity in developing hippocampal neurons and potently induces neuronal differentiation of neural stem cells.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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