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Product Details

17-AHA-Geldanamycin | Geldanamycin affinity chromatography ligand

17-AHA-geldanamycin is a semi-synthetic analog of geldanamycin containing a linker bearing a free NH2 functional group for conjugation. Selectively binds to HSP90 and may be used to prepare geldanamycin beads and affinity columns for purification of HSP90 and associated client proteins.1,2 Has been used in a copolymeric composition for geldanamycin sustained delivery and controlled release3,4 as well as other applications.

References/Citations

1) Xie et al. (2005), Geldanamycins exquisitely inhibit HGF/SF-mediated tumor cell invasion; Oncogene, 24 3697
2) Marcu et al. (2000), Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins; J. Natl. Cancer Inst., 92 242
3) Borgman et al. (2009), Biodistribution of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer drug delivery; Mol. Pharmacol. 6 1836
4) Kasuya et al. (2001), Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates; J. Control. Release, 74 203

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17-AHA-Geldanamycin | Structure | Supplier

Catalog#  10-1577-0005

$100.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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Catalog Number:
10-1577
Activity:
Geldanamycin affinity chromatography ligand
Chemical Name:
17-(6-Aminohexylamino)-17-demethoxygeldanamycin
Alternate Names:
AH-GDM
Molecular Weight:
644.80
Molecular Formula:
C34H52N4O8
Solubility:
Soluble in DMSO (up to at least 50 mg/ml)
Physical Properties:
Dark red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
FeaturedDescription:
Selectively binds to HSP90 and may be used to prepare geldanamycin beads and affinity columns for purification of HSP90 and associated client proteins
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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