17-AHA-geldanamycin is a semi-synthetic analog of geldanamycin containing a linker bearing a free NH2 functional group for conjugation. Selectively binds to HSP90 and may be used to prepare geldanamycin beads and affinity columns for purification of HSP90 and associated client proteins.1,2 Has been used in a copolymeric composition for geldanamycin sustained delivery and controlled release3,4 as well as other applications.
1) Xie et al. (2005), Geldanamycins exquisitely inhibit HGF/SF-mediated tumor cell invasion; Oncogene, 24 3697
2) Marcu et al. (2000), Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins; J. Natl. Cancer Inst., 92 242
3) Borgman et al. (2009), Biodistribution of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer drug delivery; Mol. Pharmacol. 6 1836
4) Kasuya et al. (2001), Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates; J. Control. Release, 74 203