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Compound 115-7c | HSP70 modulator

Compound 115-7c (908074-72-6) acts as an artificial co-chaperone for HSP70.1 The activity of compound 115-7c mirrors those of HSP40 stimulating the ATPase and protein-folding activities of prokaryotic HSP70. Increases tau levels in cell lines overexpressing tau.2 Induces solubilization of polyglutamine and exacerbates polyQ-mediated toxicity.3,4 Compound 115-7c is an important probe for understanding HSP70 functions.4

References/Citations

1) Wisen et al. (2010), Binding of a small molecule a the protein-protein interface regulates the chaperone activity of hsp70-hsp40;  ACS Chem. Biol., 5 611
2) Jinwal et al. (2010), Hsp70 ATPase Modulators as Therapeutics for Alzheimer’s and other Neurodegenerative Diseases;  Mol. Cell Pharmacol., 2 43
3) Chafekar et al. (2012), Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation;  ACS Chem. Biol., 7 1556
4) Walter et al. (2011), Ordered assembly of heat shock proteins Hsp26, Hsp70, Hsp90, and Hsp104, on expanded polyglutamine fragments revealed by chemical probes;  J. Biol. Chem., 286 40486

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Compound 115-7C | 908074-72-6 | Structure | Supplier

Catalog#  10-1567

$90.00
Quantity
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Catalog Number:
10-1567
CAS#:
908074-72-6
Activity:
HSP70 modulator
Chemical Name:
4-(5-((Benzyloxycarbonyl)-4-(2,4-dichlorophenyl)-6-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)butanoic acid
Alternate Names:
SW02
Molecular Weight:
477.34
Molecular Formula:
C23H22Cl2N2O5
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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