Compound 115-7c (908074-72-6) acts as an artificial co-chaperone for HSP70.¹ The activity of compound 115-7c mirrors those of HSP40 stimulating the ATPase and protein-folding activities of prokaryotic HSP70. Increases tau levels in cell lines overexpressing tau.² Induces solubilization of polyglutamine and exacerbates polyQ-mediated toxicity.^3,4 Compound 115-7c is an important probe for understanding HSP70 functions.⁴

References/Citations

1) Wisen et al. (2010), Binding of a small molecule a the protein-protein interface regulates the chaperone activity of hsp70-hsp40;  ACS Chem. Biol., 5 611
2) Jinwal et al. (2010), Hsp70 ATPase Modulators as Therapeutics for Alzheimer’s and other Neurodegenerative Diseases;  Mol. Cell Pharmacol., 2 43
3) Chafekar et al. (2012), Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation;  ACS Chem. Biol., 7 1556
4) Walter et al. (2011), Ordered assembly of heat shock proteins Hsp26, Hsp70, Hsp90, and Hsp104, on expanded polyglutamine fragments revealed by chemical probes;  J. Biol. Chem., 286 40486