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CT-2584 | Inhibitor of CTP: choline-phosphate cytidylyltransferase

CT-2584 (166981-13-1; free base) is a cytotoxic agent that alters phospholipid biosynthesis via inhibition of CTP:choline-phosphate cytidylyltransferase causing an increase in phosphatidylinositol with decreasing levels of phosphatidylcholine.1 The altered phospholipid metabolism caused by CT-2584 results in a loss of lamellar structure and membrane integrity (especially in mitochondria and endoplasmic reticulum). CT-2584 was active against a wide range of tumor cell lines including multi-drug resistant lines.2

References/Citations
1) Finney et al. (2000), Pharmacolgical Inhibition of Phosphatidylcholine Biosynthesis is Associated with Induction of Phosphatidylinositol Accumulation and Cytolysis of Neoplastic Cell lines; Cancer Res., 60 5204
2) Cheeseman et al. (2000), Phase I and pharmacologic study of CT-2584 HMS, a modulator of phosphatidic acid, in adult patients with solid tumors; Br. J. Cancer, 83 1599

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Catalog#  10-4560

$125.00
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CAS:
166981-13-1 (free base)
Catalog Number:
10-4560
Activity:
Inhibitor of CTP: choline-phosphate cytidylyltransferase
Chemical Name:
1-(11-Dodecylamino-10-hydroxyundecyl)-3,7-dimethylxanthine methane sulfonate
Molecular Weight:
629.9
Molecular Formula:
C30H55N5O3 CH3SO3H
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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