my account
Login
  Loading... Please wait...

Product Details

SU-4312 | VEGFR / PDGFR kinase inhibitor

SU-4312 (5812-07-7) is a potent selective inhibitor of VEGFR kinase (also known as Flk-1 and KDR). Inhibition of the activated kinase (IC50 = 0.4 μM) is 100-fold less than inhibition of the unactivated kinase (IC50 = 0.04 μM). SU-4312 also inhibits PDGFR kinase (IC50 = 19.4 μM).

References/Citations
1) Kendall et al. (1999), Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues; J. Biol. Chem., 274 6453
2) Sun et al. (1998), Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases; J. Med. Chem., 41 2588

swipe
Focus Biomolecules cell signaling reagent supplier, structure of SU-4312 | VEGFR / PDGFR kinase inhibitor | CAS 5813-07-7

Catalog#  10-1027

$70.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
7/7/5812
Catalog Number:
10-1027
Activity:
VEGFR / PDGFR kinase inhibitor
Chemical Name:
3-(4-Dimethylaminobenzylidene)-1,3-dihydroindol-2-one
Molecular Weight:
264.33
Molecular Formula:
C17H16N2O
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the SU-4312 | VEGFR / PDGFR kinase inhibitor to your wish list.