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Product Details

Imatinib mesylate | BCR-ABL inhibitor

Imatinib (220127-57-1) is a tyrosine kinase inhibitor specific for abl (IC50 = 0.038 μM)1, PDGF-R (IC50 = 0.3 μM)1 and c-kit (IC50 = 0.1 μM)2. It is a clinically useful anti-cancer drug approved for the treatment of chronic myelogenous leukemia, gastrointestinal stromal tumors as well as several other cancers.

References/Citations
1) Buchdunger, et al.(1996) Inhibition of the Abl Protein-Tyrosine Kinase in Vitro and in Vivo by a 2-Phenylpyrimidine Derivative; Cancer Res. 56 100
2) Heinrich et al (2000) Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood 96 925
3) Morioka et al. (2016) Effect of Collagen Type 1 or Human Fibronectin on Imatinib Cytotoxicity in Oral Squamous Cell Carcinoma; Pharmacology and Pharmacy, 7 255 [Focus Biomolecules Citation]
4) Hazekawa et al. (2017) Assessment of cytotoxicity of imatinib for oral squamous cell carcinoma by a real-time cell analysis system; E. J. Bio., 13 56 [ Focus Biomolecules Citation]

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Focus Biomolecules cell signaling reagent supplier, structure of Imatinib mesylate | BCR-ABL inhibitor | CAS 220127-57-1

Catalog#  10-1060

$30.00
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CAS:
220127-57-1
Catalog Number:
10-1060
Activity:
BCR-ABL inhibitor
Alternate Names:
Gleevec
Chemical Name:
4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate
Molecular Weight:
589.73
Molecular Formula:
C29H31N7O CH3SO3H
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Water (up to 50 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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