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Latrunculin A | Inhibits actin polymerization and microfilament organization

Latrunculin A (76343-93-6) inhibits actin polymerization and disrupts microfilament organization1. Significantly more potent than cytochalasins in the disruption of microfilamament mediated processes.2 Active in cell culture.3,4

References/Citations
1) Coue et al. (1987), Inhibition of actin polymerization by latrunculin; FEBS Lett., 213 316
2) Spector et al. (1989), Latrunculins-novel marine macrolides that disrupt microfilament organization and affect cell growth; Cell Motil. Cytoskeleton, 13 127
3) Wang et al. (2005), Differential effects of latrunculin-A on myofibrils in cultures of skeletal muscle cells: Insights into mechanisms of myofibrillogenesis; Cell Motil. Cytoskeleton, 62 35
4) Reggiori et al. (2005), The actin cytoskeleton is required for selective types of autophagy, but not for non-specific autophagy, in the yeast Saccharomyces cerevisiae; Mol. Biol. Cell, 16 5843

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Catalog#  10-2254

$98.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
76343-93-6
Catalog Number:
10-2254
Activity:
Inhibits actin polymerization and microfilament organization
Molecular Weight:
421.55
Molecular Formula:
C22H31NO5S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
B
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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