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Product Details

Mycalolide B | Actin depolymerizing agent

Mycalolide B (122752-21-0) is a novel marine natural product which binds to actin in a 1:1 molar ratio (Kd=13-20 nM).1 It selectively and completely depolymerizes F-actin to G-actin via a novel mechanism different from that of the cytochalasin D.2 It is a novel and specific inhibitor of actomyosin ATPase.3

References/Citations

1) Saito et al. (1994), Mycalolide B, a novel actin depolymerizing agent; J. Biol. Chem., 269 29710
2) Sugidachi et al. (1998), Inhibition of rat platelet aggregation by mycalolide-B, a novel inhibitor of actin polymerization with a different mechanism of action from cytochalasin-D; Thromb. Haemost., 79 614
3) Hori et al. (1993), Mycalolide-B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge; FEBS Lett., 322 151

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Catalog#  10-2217

$200.00
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CAS:
122752-21-0
Catalog Number:
10-2217
Activity:
Actin depolymerizing agent
Source:
From Mycale sp.
Molecular Weight:
1027.16
Molecular Formula:
C52H74N4O17
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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