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Wiskostatin | N-WASP inhibitor

Wiskostatin (253449-04-6) is a selective, reversible inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity1. Binds to the regulatory domain of N-WASP and inhibits activation of Arp2/3 complex by forcing N-WASP into an inactive conformation2. Inhibits PIP2-induced actin polymerization (EC50=4 μM). Wiskostatin perturbs agrin-elicited acetylcholine receptor clustering3. Inhibits the formation of dendritic spines and synapses in hippocampal neurons.

References/Citations
1) Peterson et al. (2002), Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton; Chem. Biol., 9 1275
2) Peterson et al. (2004), Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation; Nat. Struct. Mol. Biol., 11 747
3) Cartaud et al. (2011), Agrin triggers the clustering of raft-associated acetylcholine receptors through actin cytoskeleton reorganization; Biol. Cell., 103 287
4) Wegner et al. (2008), N-wasp andx the arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses; J. Biol. Chem., 283 15912

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Wiskostatin | N-WASP inhibitor | CAS 253449-04-6

Catalog#  10-1353

$55.00
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CAS:
253449-04-6
Catalog Number:
10-1353
Activity:
N-WASP inhibitor
Chemical Name:
1-(3,6-Dibromocarbazol-9-yl)-3-dimethylaminopropan-2-ol
Molecular Weight:
426.15
Molecular Formula:
C17H18Br2N2O
Solubility:
Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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