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Product Details

MCC-950 | NLRP3 inflammasome inhibitor

MCC-950 (210826-40-7) was originally found to act as a cytokine release inhibitory drug (CRID), arresting activated monocytes and preventing activation of caspase-1.1 Discovered to be a novel inhibitor of the NLRP3 and AIM2 inflammasomes.2 MCC-950 blocks canonical and noncanonical NLRP3 activation at nanomolar concentrations.3 Inhibits interleukin 1β (IL-1β) secretion in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (an MS disease model).3 Disrupts the interaction between AIM2 and ASC in a reconstituted cell-free inflammasome.4 MCC-950 is a valuable new tool for exploring the pathophysiology of NLRP3.

References/Citations

1) Laliberte et al. (2003), Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing; J. Biol. Chem., 278 16567
2) Coll et al. (2011), The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes; Clin. PLoS One, 6(12) e29539
3) Coll et al. (2015), A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory disease; Nat. Med., 21 248
4) Kaneko et al. (2015), Reconstituted AIM2 inflammasome in cell-free system; J. Immunol. Methods, 426 76

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Catalog#  10-2990-0001

$58.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
210826-40-7
Catalog Number:
10-2990
Activity:
NLRP3 inflammasome inhibitor
Chemical Name:
N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt
Alternate Names:
CRID3; CP-456773 sodium salt
Molecular Weight:
426.46
Molecular Formula:
C20H23N2O5S
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Water (up to 30 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT
FeaturedDescription:
MCC-950 blocks canonical and noncanonical NLRP3 activation at nanomolar concentrations.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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