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Andrographolide | Induces mitochondrial -mediated apoptosis in lymphoma cells

Andrographolide (5508-58-7) is the major bioactive component of the medicinal plant Andrographis paniculate. Demonstrates anti-inflammatory anti-apoptotic, anti-viral and anti-proliferative effects in vitro and in vivo. Prevents hyperglycemia in rat diabetes model. Andrographolide is an irreversible antagonist of NK-κB and AP-1 (IC50 = 15 μM)

References/Citations
1) Xia et al. (2004), Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50; J. Immunol., 173 4207
2) Chen et al. (2004), Andrographolide supresses endothelial cell apoptosis via activation of phosphatidyl inositol-3-kinase/Akt pathway; Biochem. Pharmacol., 67 1337
3) Yu et al. (2003), Antihyperglycemic effect of andrographolide is streptozotocin-induced diabetic rats; Planta Med., 69 1075

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Focus Biomolecules supplier, Andrographolide | Induces mitochondrial-mediated apoptosis in lymphoma cells | CAS 5508-58-7

Catalog#  10-1173

$34.00
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CAS:
5508-58-7
Catalog Number:
10-1173
Activity:
Induces mitochondrial -mediated apoptosis in lymphoma cells
Molecular Weight:
350.45
Molecular Formula:
C20H30O6
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 8 mg/ml).
Physical Properties:
Off-white solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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