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Obesity and Metabolic Diseases

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  • AdipoRon | 924416-43-3 | Structure | Supplier
    $50.00
    AdipoRon (924416-43-3) is a novel potent and selective adiponectin (AdipoR1 and AdipoR2) receptor agonist, Kd=1.8 and 3.1 μM respectively1. Displayed similar effects to adiponectin in muscle and liver such as activation...

  • Amlexanox | 68302-57-8 | Structure | Supplier
    $50.00
    Amlexanox (68302-57-8) improves obesity-related metabolic dysfunction in mouse models1. Amlexanox increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity. Inhibits TANK-binding kinase 1...

  • Cerulenin | Fatty Acid Synthase inhibitor
    $90.00
    Cerulenin (17397-89-6) is a fatty acid synthase (FAS) inhibitor. Binds to β-keto-acyl-ACP synthase (KAS; IC50=1.5 μM), thus inhibiting protein acylation at concentrations of 45-134 μM.1 Cerulenin produces...

  • CL-316243 | 151126-84-0 | Structure | Supplier
    $80.00
    CL-316243 (151126-84-0) is a potent and selective β-3 adrenergic receptor agonist. (EC50= 3 nM) Displays anti-obesity and anti-diabetic effects in mice. It increases brown fat thermogenesis and metabolic rate and...

  • Conduritol B epoxide | 6090-95-5 | Structure | Supplier
    $45.00
    Conduritol B epoxide (6090-95-5) is a β-Glycosidase inhibitor.1,2 May be used for generation of the “Gaucher mouse”3 and the in vitro model of the Gaucher cell4. References/Citations 1) Datta and Radin...

  • DC260126 | GPR40 antagonist
    $48.00
    DC260126 (346692-04-4) is a GPR40 receptor antagonist1. Suppresses fatty acid-induced elevation of intracellular Ca++. Inhibits palmitic acid potentiated glucoseÐstimulated insulin secretion in Min6 pancreatic β...

  • Fatostatin | 125256-00-0 | Structure | Supplier
    $50.00
    Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight,...

  • FSG67 | GPAT inhibitor
    $55.00
    FSG67 (1158383-34-6) is an inhibitor of Glycerol 3-Phosphate Acyltransferase (GPAT); IC50 = 24 μM.1 It was able to reduce food intake, decrease body weight and adiposity, enhance energy utilization as fatty acid...

  • GE-501516 | PPAR delta agonist
    $68.00
    GW-501516 (317318-70-0) is a potent and selective PPARδ (NR1C2) agonist, EC50=1.2 nM and 1000-fold selective over other PPAR subtypes.1  Induces apolipoprotein A1-mediated cholesterol efflux in vitro.1 Improves...

  • Glyburide | 10238-21-8 | Structure | Supplier
    $30.00
    Glyburide (10238-21-8) is a second generation oral hypoglycemic agent. Acts via ATP-dependent K+ channel (Kir6, KATP) block.1 Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin...

  • GSK-137647 | GPR120 agonist
    $90.00
    GSK-137647 (349085-82-1) is a potent and selective agonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pEC50s= 6.3, 6.2 and 6.1 for human, mouse and rat receptor respectively1. GSK-137647 enhances...

  • GSK-3787 | 188591-46-0 | Supplier | Structure
    $60.00
    GSK-3787 (188591-46-0) is a selective and irreversible antagonist of the peroxisome proliferator-activated receptor delta (PPARδ) plC50 = 6.6. It covalently binds to Cys 249 in the PPARδ binding site...

  • GW-9508 | 885101-89-3 | Structure | Supplier
    $65.00
    GW9508 (885101-89-3) is a selective agonist at the free fatty acid receptor, FFA1/4, (GPR40 and GPR120).1 Displays anti-allodynic and anti-hyperalgesic effects in mouse inflammatory and neuropathic pain models.2 Inhibits...

  • Isofagomine tartrate | Glucocerebrosidase activator and chaperone
    $100.00
    Isofagomine tartrate (957230-65-8) is a competitive inhibitor of human lysosomal β-glucosidase, IC50 = 0.06 μM.1 Increases the activity of N370S mutant acid β-glucosidase (GlcCerase) in Gaucher fibroblasts.2...

  • Miglitol | beta-glucosidase inhibitor / antidiabetic
    $60.00
    Miglitol (72432-03-2) is an α-glucosidase inhibitor which induces an enhanced and prolonged release of glucagon-like peptide-1, regulating appetite and stabilizing body weight in humans1. Miglitol displays...

  • ML-SA1 | 332382-54-4 | Structure  | supplier
    $75.00
    ML-SA1 (332382-54-4) is a TRPML 1,2 and 3 channel activator.1 Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2 ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is...

  • N-Oleoylphenylalanine | Endogenous Uncoupler of Mitochondrial Respiration
    $50.00
    N-Oleoylphenylalanine is an endogenous lipoamino acid produced via the action of a secreted enzyme PM20D1 produced by adipocytes. N-Oleoylphenylalanine binds directly to mitochondria and functions as an endogenous uncoupler...

  • Nobiletin | Attenuates metabolic syndrome
    $50.00
    Nobiletin (478-01-3) is a natural product isolated from citrus peels.  It has recently been shown to possess circadian clock amplitude-enhancing properties and was able to prevent metabolic syndrome in mice via a Clock...

  • Oltipraz | Nrf2 activator
    $39.00
    Ortipraz (64224-21-1) upregulates the transcription factor NRF2 and prevents insulin resistance and obesity induced by high fat diet in C57BL/6J mice1. Attenuates the progression of fibrosis in a rat model of nonalcoholic...

  • Orlistat | DAG Lipase-alpha inhibitor
    $30.00
    Orlistat (96829-58-2) is a lipase inhibitor which blocks the biosynthesis of 2-AG by inhibition of DAG lipase-α1. Inhibits pancreatic lipase and other lipases but not PLA22. Inhibits fatty acid synthase and displays...

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