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KY-226 | PTP1B inhibitor

KY-226 (CAS 1621673-53-7)  is a selective allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor (IC50 = 250 nM) with no activity at PPARγ.1 It significantly reduced plasma glucose, triglyceride, and A1c levels without weight gain in db/db mice.2 It has been suggested that KY-226’s anti-diabetic effects occur via enhancements in insulin signaling and anti-obesity effects via leptin signaling enhancements.2 KY-226 has also been shown to protect neurons from cerebral ischemia.3 This effect is mediated by restoration of tight junction proteins via activation of the Akt/FoxO1 pathway.4

References/Citations
1) Morashita (2017), Novel Non-carboxylate Benzoylsulfonamide-Based Protein Tyrosine Phosphatase 1B Inhibitor with Non-competitive Actions; Chem.Pharm.Bull. 65 1144
2) Ito et al. (2018), Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice; J.Pharmacol.Sci 137 38
3) Sun et al. (2018), Neuroprotective effects of protein tyrosine phosphatase 1B on cerebral ischemia/reperfusion in mice; Brain Res. 1694 1
4) Sun et al. (2019), KY-226 Protects Blood-brain Barrier Function Through the Akt/FoxO1 Signaling Pathway on Brain Ischemia; Neuroscience 399 89

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Catalog#  10-4004-0005

$65.00
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CAS:
1621673-53-7
Catalog Number:
10-4004
Activity:
PTP1B Inhibitor
Chemical Name:
4-(Biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide
Molecular Weight:
481.67
Molecular Formula:
C27H31NO3S2
Solubility:
Soluble in DMSO (>25 mg/ml).
Physical Properties:
Off-white solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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