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Phosphoinositides

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  • 3-Methyladenine | Autophagosome inhibitor
    $44.00
    3-Methyladenine (5142-23-4) inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K)1,2. Protects 1321N1 astrocytoma cells against pyocyanin and...

  • Alamethicin | Pore-forming antimicrobial peptide
    $35.00
    Alamethicin (27061-78-5) is a membrane permeabilizing, pore-forming agent.1 Applications include: [32P] incorporation into phosphatidylinositols2, permeabilization of sarcoplasmic reticulum vesicles3 and mitochondria4 and...

  • ALLM | 136632-32-1 | Structure | Supplier
    $60.00
    ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki = 120 nM, calpain II, Ki = 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin...

  • AS-041164 | PI3-K gamma inhibitor | Structure | Supplier
    $60.00
    AS-041164 (6318-41-8) is a potent, ATP-competitive, and isoform-selective PI3-Kinase inhibitor (IC50 = 0.07, 0.24, 1.45, and 1.70 μM for the γ, α, β, and δ isoforms respectively).1 Cell permeable...

  • CT-2584 | Inhibitor of CTP: choline-phosphate cytidylyltransferase
    $125.00
    CT-2584 (166981-13-1; free base) is a cytotoxic agent that alters phospholipid biosynthesis via inhibition of CTP:choline-phosphate cytidylyltransferase causing an increase in phosphatidylinositol with decreasing levels of...

  • CTPB | 586976-24-1 | Structure | supplier
    $45.00
    CTPB (586976-24-1) is a selective activator of p300 HAT (histone acetyltransferase) selective over PCAF (p300 CPB-associated factor).1,2 References/Citations 1) Balasubramanyam et al. (2003), Small molecule modulators of...

  • Flecainide acetate | Sodium channel blocker
    $50.00
    Flecainide acetate (54143-56-5) is an open Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner.1 Orally-active class Ic antiarrhythmic agent2,3. Inhibits hERG...

  • HTS01037 | 682741-29-3 | Structure | Supplier
    $60.00
    HTS01037 (682741-29-3) inhibits fatty acid binding proteins.  Inhibits lipolysis in 3T3-L1 adipocytes and reduces LPS-stimulated inflammation in cultured macrophages.  Acts as an antagonist of the protein-protein...

  • Lorcainide HCl | 58934-46-6 | Structure | Supplier
    $40.00
    Lorcainide hydrochloride (58934-46-6) is a voltage-gated Na+ channel blocker.1 Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation.2 Acts at the ouabain binding site of guinea pig...

  • LY 294002 | PI 3-Kinase inhibitor
    $85.00
    LY 294002 (154447-36-6) is a potent and specific inhibitor of phosphatidylinositol-3-kinase (IC50 = 1.40 μM). References/Citations1) Vlahos et al. (1994) A specific inhibitor of phosphatidylinositol 3-kinase,...

  • Naloxone HCl | Opioid receptor antagonist
    $50.00
    Naloxone (357-08-4) is a pan-opioid receptor antagonist, Ki=3.7, 9.2 and 33 nM for m, k and d opioid receptors respectively1. In clinical use in opiate abuse and overdose rescue.2 Blocks opiate- promoted wound healing.3...

  • NVP-BEZ235 | PI 3-K and mTOR inhibitor
    $50.00
    NVP-BEZ235 (915019-65-7) is a dual PI3K and mTOR kinase inhibitor.1 It inhibits VEGF-induced proliferation and angiogenesis.2 Reverses lapatinib resistance.3 It induces G1 arrest and reduces cyclin D1...

  • Optovin | 348575-88-2 | Structure | supplier
    $70.00
    Optovin (348575-88-2) is a reversible photoactive TRPA1 activator. Optovin stimulates human TRPA1 channels and enables repeated photoactivation of motor behaviors in wild-type zebrafish (EC50 = 2 μM) and mice, in vivo...

  • Phosphatidylinositol (50%) | Endogenous lipid
    $50.00
    Phosphatidylinositol (97281-52-2) is an endogenous lipid and an enzymatic substrate

  • Piperine | Up-regulates skeletal muscle metabolism
    $25.00
    Piperine (94-62-2) is a natural product isolated from black pepper that has myriad biological effects.  Piperine has recently been shown to increase the metabolic rate of resting muscle (fast twitch skeletal fibers)...

  • PX-866 | 502632-66-8 | Structure | Supplier
    $58.00
    PX-866 (502632-66-8) inhibits PI-3 Kinase with selectivity for p110α (IC50=0.1 nM). Displays antitumor activity. Irreversible. Cell permeable. References/Citations1) Ihle et al. (2004), Molecular pharmacology and...

  • Rbin-1 | Eukaryotic ribosome assembly inhibitor
    $50.00
    Rbin-1 (328023-11-6) is potent (GI50 = 136 nM) and reversible inhibitor of eukaryotic ribosome assembly.  The biochemical target of Rbin-1 is Midasin (Mdn1), an essential AAA+ protein.  Blocking of Mdn1 by Rbin-1...

  • Safracin B | Anticancer agent
    $98.00
    Safracin B (87578-99-2) is a novel antibiotic of the saframycin family produced by Pseudomonas fluorescens.1 Safracin B displays antitumor activity against L1210 and P388 leukemias and B16 melanoma. Compared with safracin A,...

  • Salermide | SIRT1 and SIRT2 inhibitor
    $50.00
    Salermide (1105698-15-4) is a SIRT1 and SIRT2 inhibitor. Exhibits a stronger inhibitory effect on SIRT2 than on SIRT1 in vitro. Induces the reactivation of proapoptotic genes repressed by SIRT1 and causes massive apoptosis...

  • SB-225002 | CXCR2 antagonist
    $60.00
    Potent and selective CXCR2 receptor antagonist (IC50 = 22 nM). Displays >150-fold selectivity over CXCR1 receptors.1 Induces apoptosis in both wild-type and p53-deficient ovarian cancer cells (OVCA) via p53 activation and...

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