my account
  Loading... Please wait...

Product Details

U-73122 | PLC inhibitor

U-73122 (112648-68-7) inhibits receptor-coupled phospholipase C-dependent processes in platelets and neutrophils via interfering with G protein-PLC interaction.1  U-73122 is a useful tool for probing the involvement of PI-PLC in receptor mediated cellular physiology and processes.2-4


1) Bleasdale et al. (1990), Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils; J. Pharmacol. Exp. Ther., 255 756
2) Zholos et al. (2004), Phospholipase C, but not InsP3 or DAG,-dependent activation of the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells; Br. J. Pharmacol., 141 23
3) Jun et al. (2004), Diacylglycerol and its formation by phospholipase C regulate Rab- and SNARE dependent yeast vacuole fusion; J. Biol. Chem. ,279 53186
4) Fernandez-Ulibarri et al. (2007), Diacylglycerol is required for the formation of COPI vesicles in the Golgi-to-ER transport pathway; Mol. Biol. Cell, 18 3250

Focus Biomolecules cell signaling reagent supplier, chemical structure of U-73122 | PLC inhibitor | CAS 112648-68-7

Catalog#  10-1061-0005

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Request Bulk Quote
Catalog Number:
PLC inhibitor
Chemical Name:
Molecular Weight:
Molecular Formula:
Very soluble in Methylene chloride or Chloroform. Slightly soluble in DMSO (up to 2 mg/ml) or in Ethanol (up to 1 mg/ml).
Physical Properties:
White or off-white solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Room temperature
Stable for 1 year as supplied. Use caution when storing DMSO solutions. Typically solutions in DMSO can be stored at -20°C for approximately 2 months. However, any solutions that turn pink should be discarded.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the U-73122 | PLC inhibitor to your wish list.