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Product Details

U-73122 | PLC inhibitor

U-73122 (112648-68-7) inhibits receptor-coupled phospholipase C-dependent processes in platelets and neutrophils via interfering with G protein-PLC interaction.1  U-73122 is a useful tool for probing the involvement of PI-PLC in receptor mediated cellular physiology and processes.2-4

References/Citations

1) Bleasdale et al. (1990), Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils; J. Pharmacol. Exp. Ther., 255 756
2) Zholos et al. (2004), Phospholipase C, but not InsP3 or DAG,-dependent activation of the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells; Br. J. Pharmacol., 141 23
3) Jun et al. (2004), Diacylglycerol and its formation by phospholipase C regulate Rab- and SNARE dependent yeast vacuole fusion; J. Biol. Chem. ,279 53186
4) Fernandez-Ulibarri et al. (2007), Diacylglycerol is required for the formation of COPI vesicles in the Golgi-to-ER transport pathway; Mol. Biol. Cell, 18 3250

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U-73122 | 112648-68-7 | Structure | Supplier

Catalog#  10-1061-0005

$56.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
112648-68-7
Catalog Number:
10-1061
Activity:
PLC inhibitor
Chemical Name:
1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione
Molecular Weight:
464.65
Molecular Formula:
C29H40N2O3
Solubility:
Very soluble in Methylene chloride or Chloroform. Slightly soluble in DMSO (up to 2 mg/ml) or in Ethanol (up to 1 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
Room temperature
Stability:
Stable for 1 year as supplied. Use caution when attempting to resuse stored DMSO solutions. Typically solutions in DMSO can be stored at -20°C for approximately 2 months. However, any solutions that develop a pink color after storage should i
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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