Tianeptine sodium salt | Neuroprotective agent

CAS:
30123-17-2
Catalog Number:
10-2937
Activity:
Neuroprotective agent
Chemical Name:
7-[(3-chloro-6,11-dihydro-6-methyl-5,5-dioxidibenzo[c,f][1,2]thiazepin-11-yl)amino]heptamoic acid, sodium salt
Molecular Weight:
458.93
Molecular Formula:
C21H24ClN2O4S
Solubility:
Soluble in DMSO (up to 5 mg/ml) or in Water (up to 45 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
10 mg$40.00
50 mg$100.00

Tianeptine sodium salt (30123-17-2) is a selective enhancer of serotonin uptake in the brain with no effect on noradrenalin or dopamine uptake.1 Clinically useful antidepressant.2 Displays neuroprotective effects against hypoxia in cell culture and against the deleterious effects of cytokines in vivo.3 Induces mTORC1 activation in rat hippocampal neurons and increases dendritic outgrowth, spine density and synaptic proteins.4 Attenuates LPS-evoked inflammatory activation of microglial cells in culture.5

References/Citations

1) Mennini et al. (1987), Tianeptine, a selective enhancer of serotonin uptake in rat brain;  Naunyn-Schmied. Arch. Pharmacol., 336 478
2) Kato and Weitsch (1988), Neurochemical profile of tianeptine, a new antidepressant drug;  Clin. Neuropharmacol., 11 S43
3) Plaisant et al. (2003), Neuroprotective properties of tianeptine: interactions with cytokines; Neuropharmacology, 44 801
4) Seo et al. (2016), Tianeptine induces mTORC1 activation in rat hippocampal neurons under toxic conditions;  Psychopharmacology (Berl.), 233 2617
5) Slusarczyk et al. (2017), Anti-inflammatory properties of tianeptine on lipopolysaccharide-induced changes in microglial cells involve toll-like receptor-related pathways;  J. Neurochem., 136 958

CAS:
30123-17-2
Catalog Number:
10-2937
Activity:
Neuroprotective agent
Chemical Name:
7-[(3-chloro-6,11-dihydro-6-methyl-5,5-dioxidibenzo[c,f][1,2]thiazepin-11-yl)amino]heptamoic acid, sodium salt
Molecular Weight:
458.93
Molecular Formula:
C21H24ClN2O4S
Solubility:
Soluble in DMSO (up to 5 mg/ml) or in Water (up to 45 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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