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Product Details

Nalmefene HCl | Opioid receptor antagonist

Nalmefene (58895-64-0) is an opioid antagonist. Very similar activity profile to naloxone (Cat.# 10-2442) however displays slower onset and longer duration of action1. Antagonizes the effects of salvinorin2 (κ-agonist) as well as herkinorin3 (μ-agonist). Nalmefene as been used as a therapeutic for treatment of alcohol dependence4.

1) Osborn et al. (2010), In vivo characterization of the opioid antagonist nalmefene in mice; Life Sci., 86 624
2) Butelman et al. (2009), Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in non-human primates: fast onset and entry in cerebrospinal fluid; J. Pharmacol. Exp. Ther., 328 588
3) Butelman et al. (2008), The effects of herkinorin, the first mu-selective ligand from salvinorin A-derived scaffold, in neuroendocrine biomarker assay in nonhuman primates; J. Pharmacol. Exp. Ther., 327 154
4) Soyka and Rosner (2008), Opioid antagonists for pharmacological treatment of alcohol dependence - a critical review; Curr. Drug Abuse Rev., 1 280

Focus Biomolecules cell signaling reagent supplier, structure Nalmefene HCl | Opioid receptor antagonist | CAS 58895-64-0

Catalog#  10-1049

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Catalog Number:
Opioid receptor antagonist
Chemical Name:
5(α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylene-morphinan-3,14-diol hydrochloride
Molecular Weight:
Molecular Formula:
C21H25NO3 HCl
Soluble in Water (up to 25 mg/ml).
Physical Properties:
White solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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