Nalmefene (58895-64-0) is an opioid antagonist. Very similar activity profile to naloxone (Cat.# 10-2442) however displays slower onset and longer duration of action¹. Antagonizes the effects of salvinorin² (κ-agonist) as well as herkinorin³ (μ-agonist). Nalmefene as been used as a therapeutic for treatment of alcohol dependence⁴.

References/Citations
1) Osborn et al. (2010), In vivo characterization of the opioid antagonist nalmefene in mice; Life Sci., 86 624
2) Butelman et al. (2009), Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in non-human primates: fast onset and entry in cerebrospinal fluid; J. Pharmacol. Exp. Ther., 328 588
3) Butelman et al. (2008), The effects of herkinorin, the first mu-selective ligand from salvinorin A-derived scaffold, in neuroendocrine biomarker assay in nonhuman primates; J. Pharmacol. Exp. Ther., 327 154
4) Soyka and Rosner (2008), Opioid antagonists for pharmacological treatment of alcohol dependence - a critical review; Curr. Drug Abuse Rev., 1 280