We will continue to add new products to our already extensive portfolio – check back often for the latest breakthroughs. If you can’t find what you need, contact us for information on custom synthesis.

New Products
The ß-cyclodextrin complex of Mitoquinone mesylate is an easier to use, less deliquescent form of the useful mitochondrial antioxidant Mitoquinone....
$80.00$280.00

PFI-3 is a selective inhibitor of family VIII bromodomains PB1(5), SMARCA2, and SMARCA4.1 It showed complete selectivity over all non-family VIII b...
$59.00$215.00

JQ1 (+) (1268524-70-4) is a potent BET bromodomain inhibitor and is the active isomer.   IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2...
$100.00$400.00

Ceapin-A7 (2323027-38-7) is a selective inhibitor (IC50 = 590 nM) of transcription factor ATF6a, one of the three branches of the unfolded protein ...
$75.00$295.00

Ceapin-A7 (2323027-38-7) is a selective inhibitor (IC50 = 590 nM) of transcription factor ATF6a, one of the three branches of the unfolded protein ...
$75.00$295.00

Saxagliptin (709031-78-7) is a clinically useful DPPIV inhibitor for the treatment of diabetes.1  Human DPP-IV Ki = 0.6 nM.2 References: Ta...
$39.00$140.00

Belnacasan (273404-37-8) is a prodrug of VRT-043198, a potent (Ki = 0.8 nM ICE/caspase-1; <0.6nM caspase-4) and selective inhibitor of interleuk...
$45.00$160.00

Enzalutamide (915087-33-1) is a clinically useful non-steroidal antiandrogen (IC50 = 36 nM) for the treatment of castration-resistant prostate canc...
$50.00$175.00

WP631 is a novel bisintercalating anthracycline. Potent inhibitor of Sp1-activated transcription.1,2 Induces caspase-dependent apoptosis in human o...
$65.00$270.00

CCT251236 (1693731-40-06) is an inhibitor of the Heat Shock Transcription Factor 1 (HSF1) stress pathway (IC50 = 19 nM Inhibition HSF-1 mediated HS...
$90.00$325.00

AZD-2098 is a potent, orally bioavailable antagonist of CCR4 (pIC50 = 7.8(h), 8.0(r), 8.0(m), 7.6(d)).1 Inactive at CXCR1/2, CCR1, CCR2b, CCR5, CCR...
$50.00$185.00

PTC-209 is an inhibitor of BMI-1 (IC50 = 500 nM), part of the polycomb repressive complex 1 (PCR1).1  It inhibited endogenous BMI-1 expression in h...
$65.00$240.00

PB28 (172907-03-8) is a very potent high affinity (Ki = 5.3 nM1, 0.34 nM2) σ2 agonist.  Selective for σ2 over σ1 (approx 30-40x).1,2 PB28 inhibited...
$45.00$160.00

Thiolutin (87-11-6) inhibits the deubiquitinating (DUB) activity of PSMD14 exhibiting potent antitumor activity in neck squamous cell carcinoma in ...
$60.00$186.00

MDL-800 (2275619-53-7) is an allosteric activator of SIRT6 (EC50 = 10.3 µM).1 It specifically activates the deacetylase (H3K9ac and H3K56ac) activi...
$85.00$315.00

Buparlisib (944396-07-0) is potent pan-Class I PI3-kinase inhibitor (IC50’s: p110a = 52 nM, p110b = 166 nM, p110d = 116 nM. P110g = 262 nM).1,2 It ...
$70.00$265.00

Autogramin-2 (2375541-45-8) is an inhibitor of autophagy (autophagy induced by amino acid starvation IC50 = 270 nM; Rapamycin IC50 = 140 nM) acting...
$70.00$275.00

Ganetespib (888216-25-9) is an inhibitor of heat shock protein 90 (IC50 = 19 nM, canine C2 malignant mast cells; 4 nM, canine BR malignant mast cel...
$65.00$250.00

CDN1163 (892711-75-0) is an allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA).1,2  It lowered fasting glucose levels, imp...
$55.00$185.00

BIIB021 is a potent HSP90 inhibitor (IC50 = 30 nM HER-2 degradation).1 It inhibited the proliferation of MCF7 and BT474 breast cancer cell lines (I...
$50.00$175.00

Glumetinib (1642581-63-2) is a highly selective (2400-fold selectivity against a panel of 312 kinases) and potent (IC50 = 0.42 nM) inhibitor of c-M...
$90.00$325.00

GSK8612 is a highly selective and potent (avg. pIC50 = 6.8 versus recombinant TBK1) inhibitor of Tank-binding Kinase-1 (TBK1) with higher affinity ...
$95.00$370.00

NVP-231 (362003-83-6) is a reversible inhibitor of ceramide kinase (IC50 = 12 nM).1 At 10 nM, it inhibited ceramide-1-phosphate formation by >50...
$40.00$130.00

PBD-150 (790663-33-1) is an inhibitor of human glutaminyl cyclase (IC50 = 60 nM).1 PBD-150 diminished Ab plaque formation and gliosis while improvi...
$60.00$225.00

TASIN-1 selectively induces apoptosis in cells with truncations in the adenomatous polyposis coli (APC) gene (but not normal cells or wild type can...
$70.00$275.00

GRL-0667 is a potent (IC50 = 320 nM) noncovalent inhibitor of severe acute respiratory syndrome-coronavirus papain-like protease (SARS-CoV PLpro). ...
$95.00$370.00

Bepridil is a clinically useful calcium channel blocker with antianginal activity.1 It has recently been shown to possess potent activity against S...
$40.00$125.00

DAPI (28718-90-3) is a fluorescent DNA stain for use on fixed cells for applications such as imaging, mitochondrial DNA detection1, or nuclear quan...
$40.00$130.00

Isohelenin (470-17-7) is a sesquiterpene lactone isolated from Mexican Indian medicinal plants known to have anti-inflammatory properties. A potent...
$50.00$180.00

CID1067700 (314042-01-8) is a specific competitive inhibitor of nucleotide binding to Rab7, an endosome-localized small GTPase.1 It interferes with...
$65.00$240.00

A potent inhibitor of PI-3 kinase, mTOR and DNA-PK, IC50 = 8, 88, 150, 48,  20, 83 and 2 nM for p110α, p110ß, p110γ, p110δ, mTORC1, mTORC2 and DNA-...
$60.00$240.00

RU.521 is an inhibitor of cyclic GMP-AMP synthase (cGAS), an important innate immune system sensor of foreign cytoplasmic double-stranded DNA.1,2 I...
$95.00$325.00

ABX-1431 is potent (IC50 = 14 nM in vitro, 2.2 nM in human PC3 cells) and very selective (>100-fold over hABHD6, >200-fold over hPLA2G7) inhi...
$60.00$235.00

Flumazenil (78755-81-4) is a benzodiazepine antagonist1, panspecific for α1, α2, α3 or α5-containing GABAA receptors2.  Reduces withdrawal sequelae...
$50.00$200.00

Verteporfin (129497-78-5) inhibits transcription by YAP/TAZ, IC50 = 2.5 µM, (via disruption of YAP-TEAD interaction) inhibiting autophagy and halti...
$75.00$300.00

DJ001 (2161306-12-8) is a potent and specific inhibitor of receptor type protein tyrosine phosphatase-sigma (PTPσ) IC50=1.54 µM and >10 µM for 2...
$70.00$300.00

KL101 (396721-89-4) is an isoform-selective stabilizer of the circadian clock protein CRY1.  It dose-dependently lengthened the circadian period in...
$70.00$305.00

TH301 (450338-32-6) is an isoform-selective stabilizer of the circadian clock protein CRY2.  It dose-dependently lengthened the circadian period in...
$80.00$325.00

Mitoquinone mesylate (845959-50-4) is a mitochondria-targeted antioxidant.  Displays cardio- and neuroprotective effects.1 Displays beneficial effe...
$70.00$240.00

Picotamide is an antiplatelet agent that inhibits both thromboxane A2 and thromboxane A2 synthase.1-3 References/Citations Modesti, et al. ...
$75.00$295.00

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Torin 1 (1222998-36-8) is a potent and selective ATP-competitive mTOR inhibitor, IC50=2 and 10 nM for mTORC1 and mTORC2 respectively.1,2 Active in ...
$70.00$280.00

Guggulsterone-(Z) (39025-23-5) is a natural steroid from Commiphora mukul extract (guggulipid) which lowers cholesterol and acts as an FXR antagoni...
$76.00$300.00

Remodelin (949912-58-7) is a potent and selective inhibitor of N-acetyltransferase 10 (NAT10) which is capable of acetylating microtubules and hist...
$65.00$280.00

TIC10 (1616632-77-9) is novel anti-cancer compound that acts via early-stage integrated stress response activation leading to selective cancer cell...
$50.00$195.00

GKT-137831 (1218942-37-0) is an NADPH oxidase, NOX1/4 inhibitor (Ki = 100-150 nM).1  Inhibits erastin-stimulated ROS production.2 Potentiates immun...
$70.00$280.00

Ritonavir (155213-67-5) is a clinically useful HIV-1/HIV-2 protease inhibitor.1 Potent inhibitor of cytochrome P450 3A4.2,3   References...
$40.00$150.00

Oseltamivir phosphate (204255-11-9) is a potent viral neuraminidase inhibitor and a clinically useful treatment for influenzas A and B.1,2 Oseltami...
$30.00$110.00

Tiagabine (145821-59-6) is a clinically useful anticonvulsant.1 It is also used to treat anxiety/panic disorder2 and neuropathic pain3. Tiagabine i...
$35.00$125.00

GRL-0617 (1093070-16-6) is a potent (IC50 = 600 nM) noncovalent inhibitor of severe acute respiratory syndrome-coronavirus papain-like protease (SA...
$75.00$250.00

Nelfinavir mesylate (159989-65-8) is a clinically useful anti-HIV agent acting via inhibition of HIV-1 protease (Ki=2 nM).1 It also displays effica...
$50.00$175.00

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Prochlorperazine maleate (84-02-6) inhibits dynamin and clathrin-mediated endocytosis (CME) with an IC50=5.8 µM for CME.1 Increases tumor cell anti...
$180.00$550.00

Favipiravir is an inhibitor of Influenza viruses A, B, and C (IC50’s: A = 0.03-0.20 µg/mL H1N1, 0.01-0.30 H2N2, 0.08-0.48 H3N2, 0.14-0.15 H4N2, 0.2...
$45.00$160.00

Ponatinib (943319-70-8) is a highly potent pan-Bcr-Abl and multikinase inhibitor, suppressing the activity of native Bcr-Abl (IC50=0.37 nM) as well...
$50.00$170.00

Tazemetostat (1403254-99-8) is a potent (Ki = 2.5nM wild type human PRC2-containing) and selective SAM-competitive inhibitor of the lysine methyltr...
$55.00$175.00

GRL-0496 (1087243-14-8) is a potent (IC50 = 30 nM in cell culture assays) inhibitor of severe acute respiratory syndrome-coronavirus chymotrypsin-l...
$60.00$225.00

Roxatidine (78273-80-0) is a novel histamine H2 receptor antagonist.1 Suppresses inflammatory responses via inhibition of NFκB and p38 MAPK activat...
$90.00$360.00

Brequinar sodium (96201-88-6) is an inhibitor of dihydroorotate dehydrogenase (DHODH)1,2 with IC50’s between 0.2 and 5.8 µM in various cell lines3 ...
$70.00$275.00

Dihydroresveratrol (58436-28-5) is a metabolite of resveratrol produced by gut microbiota.1-3 Glucoronide conjugates are found in human urine after...
$50.00$180.00

Scriptaid (287383-59-9) inhibits histone deacetylases (HDAC) 1 and 3 (IC50~0.6 μM) and HDAC8 (IC50~1 μM) and is less toxic compared to trichostatin...
$70.00$260.00

N4-Hydroxycytidine (3258-02-4) was originally identified as a mutagen effecting AT to GC base-pair transitions.1 It has also been found to have ant...
$70.00$250.00

Camostat mesilate (59721-29-8) is a serine protease inhibitor inhibiting plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancrea...
$40.00$125.00

PK150 (2165324-62-7) is a Sorafenib analog that displays significant antibacterial activity against several pathogenic strains (S.aureus NCTC8325, ...
$55.00$195.00

DY131 (95167-41-2) is a selective agonist at estrogen-related receptors ERRβ and ERRγ with minimal activity at ERRα, ERα and ERβ at concentrations ...
$42.00$180.00

Leelamine HCl (16496-99-4) is a lysosomotropic, intracellular cholesterol transport inhibitor with potential chemotherapeutic activity. Induces cho...
$50.00$200.00

Santacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca...
$40.00$160.00

Fruquintinib (1194506-26-7) is a potent and highly selective inhibitor of VEGFR kinase (IC50’s: VEGFR1= 33 nM, VEGFR2 = 35 nM, VEGFR3 = 0.5 nM).1 I...
$75.00$255.00

AZ20 (1233339-22-4) is a potent and highly selective inhibitor of Ataxia telangiectasia mutated and RAD3-related (ATR) kinase (IC50 = 5 nM in vitro...
$60.00$200.00

AZD1152-HQPA (722544-51-6) is a potent and highly selective inhibitor of Aurora B.1 Aurora B Ki = 0.36 nM; Aurora A Ki = 1,369 nM.2 It inhibits the...
$50.00$150.00

Lomeguatrib (192441-08-0) is a potent (IC50 = 9 nM) inhibitor of O6-Methylguanine-DNA Methyltransferase (MGMT), an important DNA repair protein.1 I...
$50.00$195.00

Levetiracetam (102767-28-2) is a clinically useful non-classical anticonvulsant.1 It has no effect on voltage-dependent Na+ channels, GABAergic tra...
$45.00$70.00

Tigecycline (220620-09-7) is a clinically useful antibiotic.1,2 It is a glycylcycline derivative of minocycline that binds to the 30S ribosomal sub...
$50.00$195.00

Volasertib (755038-65-4) is an extremely potent and selective inhibitor (IC50’s: Plk1= 0.87 nM, Plk2 = 5 nM, Plk3 = 56 nM) of Polo-like kinase 1, a...
$80.00$275.00

SNS-314 mesylate (1146618-41-8) is a potent and selective pan-Aurora kinase inhibitor (IC50’s: Aurora A = 9 nM, Aurora B = 31 nM, Aurora C = 3 nM)....
$70.00$250.00

Elafibranor (923978-27-2) is a dual PPARα/δ agonist (EC50 PPARα = 10-20 nM; PPARδ = 100-150 nM).1 It was able to decrease plasma triglycerides leve...
$65.00$235.00

Methoprene Acid (53093-52-7) is an analog of insect juvenile hormone which acts as an insect growth regulator. Binds directly and selectively to th...
$70.00$280.00

NU7441 (503468-95-9) is a potent (IC50 = 13 nM) and selective ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK).1,2 It increased t...
$50.00$175.00

AZD7762 (860352-01-8, free base) is a potent and selective inhibitor of checkpoint kinases 1 and 2 (IC50 = 5 nM for both).1 It abrogates DNA damage...
$60.00$200.00

AZ3146 (1124329-14-1) is a potent (IC50 = 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor.1 Mps1 has an essential role in the ...
$60.00$195.00

NOTUM is a carboxylesterase which depalmitoylates Wnt proteins which results in disruption of Wnt signaling.1 NOTUMib-1 inhibits the carboxylestera...
$55.00$220.00

MitoBloCK-12 (522-51-0) attenuates mitochondrial protein import (4-10 μM). Discovered in a screen of FDA-approved drugs. Blocks translocation of a ...
$40.00$130.00

Two-pore domain potassium (K2P) channels of the TREK subfamily regulate neuronal excitability, influence pain, temperature perception and responses...
$55.00$220.00

DO264 (2301866-59-9) is a potent, reversible competitive inhibitor of ABHD12 (α/β-hydrolase domain-containing 12) which shows negligible interactio...
$70.00$280.00

N-eicosanoyl serotonin is a natural product found in coffee which synergizes with caffeine in protecting the brain in models of α-synucleinopathy.1...
$50.00$180.00

Pomalidomide (19171-19-8) is a thalidomide analog that inhibits cereblon (CRBN), an E3 ubiquitin ligase, IC50 ~3 μM for CRBN-DDB1 complex.1 Display...
$50.00$150.00

Acalabrutinib (1420477-60-6) is a highly selective, potent (IC50 = 3 nM), and irreversible inhibitor of Bruton’s tyrosine kinase (BTK).1 Improved t...
$45.00$145.00

Norfluoxetine HCl (57226-68-3) is a metabolite of fluoxetine.3 Induces long QT syndrome via slow delayed rectifier potassium current block.1 Time d...
$60.00$200.00

Imiquimod (99011-02-6) is a Toll-like receptor 7/8 agonist with anti-viral and anti-tumor properties.1 Enhances innate immune system leading to Th1...
$30.00$75.00

Rucaparib phosphate (459868-92-9) is a potent (Ki<5 nM) PARP1 inhibitor.1 Cytotoxic to human cancer cells or xenograft tumors with mutated or ep...
$70.00$280.00

Ibrutinib (936563-96-1) is a very potent (IC50 = 0.5nM) irreversible inhibitor of Bruton tyrosine kinase (BTK) that blocks activation of the B-cell...
$40.00$125.00

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Home » New Products

We will continue to add new products to our already extensive portfolio – check back often for the latest breakthroughs. If you can’t find what you need, contact us for information on custom synthesis.

Home >> New Products

NEW PRODUCTS

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