We will continue to add new products to our already extensive portfolio – check back often for the latest breakthroughs. If you can’t find what you need, contact us for information on custom synthesis.
New Products
Propidium iodide (25535-16-4) is a red fluorescent DNA stain.1,2 Membrane impermeable to live cells but permeable to dead or damaged cells and thus...
$40.00 – $90.00
GSK620 (2088410-46-0) is a BET inhibitor 220-fold more selective for BD2 over BD1 (pIC50 BD2 = 7.1; BD1 = 4.8).1 It ameliorated collagen-induced ar...
$60.00 – $225.00
GSK2606414 (1337531-36-8) is a potent (IC50 = 0.4 nM) and selective (against a panel of 294 kinases) inhibitor of protein kinase R-like endoplasmic...
$65.00 – $205.00
Surfactin (24730-31-2) is a lipopeptide biosurfactant2 which displays various activities including antifungal and antibacterial as well as inhibiti...
$50.00 – $150.00
TETi76 ester (1451750-73-4) is a cell permeable inhibitor of TET dioxygenases (IC50s: TET1 = 1.5 µM; TET2 = 9.4 µM; TET3 = 8.8 µM), indirect (via ...
$75.00 – $275.00
Bempedoic acid (738606-46-7) is an inhibitor of ATP citrate lyase (ACL) and activator of AMPK used in the treatment of hypercholesterolemia.1,2 In ...
$45.00 – $125.00
VY-3-135 (1824637-41-3) is a potent (IC50 = 44 nM) and selective inhibitor of acetyl-CoA synthetase 2 (ACSS2), an enzyme that is upregulated in nut...
$120.00 – $425.00
KL044 (1801856-93-8) is a potent stabilizer of the circadian clock protein cryptochrome (CRY).1 It lengthened the circadian period and repressed Pe...
$90.00 – $340.00
Dubermatinib (1341200-45-0) is a potent (IC50 = 27 nM) inhibitor of the TAM family kinase AXL.1 It displayed potent activity against the pancreatic...
$60.00 – $225.00
N-Acetyl-L-cysteine (616-91-1) is a thiol-containing antioxidant.1 N-Acetyl-L-cysteine acts as a scavenger of reactive oxygen species (ROS) and is ...
$25.00 – $58.00
Milbemectin (1799297-76-9) is an allosteric agonist at the Drosophila RDL GABA receptor.1,2 Also acts as an agonist at glutamate-gated chloride cha...
$110.00 – $440.00
WS6 (1421227-53-3) stimulates human β-cell proliferation both in a dispersed islet proliferation assay and in intact human cultures.1 It has been ...
$75.00 – $280.00
Isothiocyanate constituents of cruciferous vegetables are potent chemopreventive agents for carcinogen-induced cancers in rodents.1 PHITC (133920-0...
$50.00 – $100.00
PD 123319 (136676-91-0) is a potent (IC50 = 34 nM) and selective non-peptide angiotensin II type 2 (AT2) antagonist.1 Ameliorated symptoms of 2,4-d...
$75.00 – $250.00
PF-543 (1706522-79-3) is a potent (IC50 = 2.0 nM) and selective (>100-fold over SphK2) reversible inhibitor of sphingosine kinase-1 (SphK1).1 It...
$75.00 – $270.00
Z-Leu-Leu-Leu-vinylsulfone (193482-47-2) blocks the trypsin-like, chymotrypsin-like, and peptidylglutamyl peptidase activity in isolated proteasome...
$175.00 – $695.00
SR3335 (293753-05-6) is a selective RORα partial inverse agonist (IC50 = 480 nM) – displays no activity at RORß, RORγ, or FXR.1 It was able to supp...
$80.00 – $275.00
Autophinib (1644443-47-9) inhibits autophagy induced by starvation or rapamycin by inhibiting the lipid kinase VPS34 (IC50=19 nM).1 Increased autop...
$80.00 – $220.00
Oligomycin A (OA) inhibits mitochondrial F1F0 ATP synthase.1 A useful tool for decreasing cellular ATP levels.2 Induces autophagy.3 Evokes maximum ...
$54.00 – $132.00
AP39 (1429173-57-8) is a mitochondrially targeted hydrogen sulfide donor. At lower concentrations (30 -100 nM), it acts as an electron donor and s...
$110.00 – $425.00
SU9516 (377090-84-1) is a cyclin-dependent kinase inhibitor, IC50s= 0.02-0.03, 0.04-0.2, 0.2-1.7 and 0.9 µM for cdk2, cdk1, cdk4, cdk9 respectively...
$75.00 – $258.00
Phenylacetyl-L-glutamine (28047-15-6) is a microbial-mammalian host co-metabolite which increases with age1 and especially in extreme longevity2. G...
$48.00 – $170.00
CDDO-Me (218600-53-4) is a potent activator of Nrf2 target transcription via interaction with thiol groups of Keap1, an Nrf2 partner, in phase 2 re...
$60.00 – $198.00
SGC-iMLLT (2255338-25-9) is a potent (IC50 = 260 nM) inhibitor of the YEATS domain of MLLT1/3.1 YEATS domain containing proteins bind acetyl and cr...
$75.00 – $285.00
4-Bromo-A23187 (76455-48-6) is a non-fluorescent analog1 of calcium ionophore A-231872 which may be used in experiments employing fluorescent probe...
$110.00 – $475.00
TH10785 (1002801-51-5) is an 8-oxo guanine DNA glycosylase 1 (OGG1) activator. Oxidative DNA damage is recognized by OGG1 which then excises 8-oxog...
$65.00 – $260.00
Elesclomol (488832-69-5) induced oxidative stress in cancer cells via rapid generation of reactive oxygen species.1 It preferentially binds copper ...
$60.00 – $195.00
BMH-21 (896705-16-1) is a planar heterocyclic DNA intercalator that inhibits RNA polymerase I (Pol I), IC50 = 0.6 µM in U2OS cells, but not Pols II...
$52.00 – $210.00
DS18562881 (2227149-22-4) is a potent (IC50 = 6.3 nM) and selective (>90-fold over MTHFD1) inhibitor of the mitochondrial enzyme methylenetetrah...
$100.00 – $375.00
PF-670462 (950912-80-8) is a potent inhibitor of casein kinase 1ε/δ (CK1ε, IC50 = 7.7 nM; CK1δ, IC50 = 14 nM).1 It is a circadian clock modifier th...
$75.00 – $275.00
GO289 (694522-87-7) is a potent inhibitor of casein kinase 2 (CK2; IC50 = 7 nM).1 Showed no inhibition of DYRK, HIPK, CLK, and PIM family kinases. ...
$95.00 – $350.00
BRD73954 (1440209-96-0) is a selective inhibitor of histone deacetylases (HDACs) 6 (IC50 = 36 nM) and 8 (IC50 = 120 nM).1
References/Citations:
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$60.00 – $195.00
SR1078 (1246525-60-9) is an agonist of the orphan nuclear receptors RORα and RORγ.1 It attenuated intrapancreatic pathological changes in mouse mod...
$70.00 – $225.00
iJMJD6 (899548-78-8) is an inhibitor of the arginine demethylase JMJD6 (IC50 = 220 nM) with selectivity over other JmjC domain-containing proteins....
$75.00 – $285.00
GSK2830371 is (1404456-53-6) a potent allosteric inhibitor of WIP1 phosphatase (IC50 = 6 nM), a negative regulator of the DNA damage response.1 It ...
$70.00 – $255.00
BI-9564 (1883429-22-8) is a potent, selective, and cell permeable inhibitor of the BRD9 bromodomain, a subunit of the switch/sucrose nonfermentable...
$60.00 – $195.00
WM-1119 is a potent and selective inhibitor of the MYST family histone acetyltransferase (HAT) KAT6A (MOZ) – IC50 = 6.3 nM.1,2 Induces cell cycle e...
$60.00 – $195.00
BIBR1532 (321674-73-1) is a non-competitive specific inhibitor of telomerase (IC50 = 93 nM), targeting telomerase reverse transcriptase (hTERT).1,2...
$60.00 – $195.00
Visomitin (934826-68-3) is a mitochondria-targeted antioxidant.1,2 A useful tool for studying mitochondrial oxidative stress involvement in many di...
$50.00 – $160.00
Lonidamine is an antiglycolytic drug with limited efficacy.1,2 Mito-lonidamine (2361564-49-8) is lonidamine conjugated to a triphenylphosphonium mo...
$100.00 – $400.00
PLX4720 (918505-84-7) is a potent and selective inhibitor of B-Raf, V600E mutant, IC50=13 nM (Wild type IC50=160 nM).1 It induces cell cycle arrest...
$55.00 – $145.00
GSK4112 (1216744-19-2) is a selective Rev-Erbα agonist (EC50=250 nM).1,2 It induces circadian clock phase shifts in isolated primary lung fibroblas...
$55.00 – $200.00
Urolithin A (1143-70-0) is a microbial metabolite of dietary ellagitannins produced in the gut.1 It has been shown to induce mitophagy and prolong ...
$50.00 – $145.00
AZD5904 (618913-30-7) is a mechanism-based inactivator of myeloperoxidase (IC50 = 200 nM), reacting with hydrogen peroxide in neutrophils to inacti...
$80.00 – $280.00
LMK235 (1418033-25-6) is a potent and selective inhibitor of HDAC4 (IC50 = 11.9 nM) and HDAC5 (IC50 = 4.2 nM).1 Cytotoxic against human ovarian can...
$60.00 – $225.00
Altretamine (645-05-6) induces ferroptosis by inhibiting glutathione peroxidase 4 (GPX4) which causes accumulation of lipid hydroperoxides.1 Ferrop...
$35.00 – $100.00
(5Z)-7-Oxozeaenol (253863-19-3) is a potent and selective inhibitor of TAK1 (mitogen activated protein kinase kinase kinase) IC50 = 8 nM.1 Selectiv...
$90.00 – $380.00
Domoic acid (DA; 14277-97-5)), a kainic acid-type neurotoxin produced by certain species of the marine pennate diatom Pseudo-nitzschia, is responsi...
$160.00
Apixaban (503612-47-3) is a potent and selective inhibitor of both free and prothrombin-bound factor Xa, Ki = 0.8 nM.1 Clinically useful antithromb...
$50.00 – $185.00
BG45 (926259-99-6) is a potent and selective HDAC3 inhibitor (IC50 = 289 nM), IC50s for HDAC1, 2 and 6 = 2, 2.2 and >20 mM respectively.1 Inhibi...
$60.00 – $240.00
N-Myristoylglycine (14246-55-0) is an endogenous lipid which was found to differentiate adipocyte precursors and white-biased adipocytes into funct...
$60.00 – $240.00
UNC7467 is a potent inhibitor of inositol hexakisphosphate kinase (IP6K) – the isoform IP3K1 regulates metabolism, promotes insulin secretion from ...
$70.00 – $270.00
Atazanavir (198904-31-3) is an azapeptide-based inhibitor of HIV protease (Ki = 2.66 nM).1 Inhibits SARS-CoV-2 main protease (Ki = 703 nM), but not...
$65.00 – $160.00
STF-118804 (894187-61-2) is a potent and selective next generation inhibitor of nicotinamide phosphoribosyl transferase (NAMPT), inhibiting NAD+ bi...
$70.00 – $280.00
iBAP-II (1013813-81-4) is an inhibitor of the H2AK119 deubiquitinase BAP1 (IC50 = 0.092 µg/ml). It is selective for BAP1 over UCHL5, USP5,7,8, TNF...
$85.00
TTNPB is a highly potent and selective retinoic acid analog acting as an RAR agonist (EC50 = 21, 4 and 2.4 nM for RARα, RARβ and RARγ respectively)...
$64.00 – $220.00
Serodolin (1814929-81-1) is a potent dual antagonist of the serotonin receptors 5-HT7 (Ki = 6.2 nM; IC50 = 5.7 nM cAMP response) and 5-HT2A (Ki = 1...
$80.00 – $295.00
Veliparib (912445-05-7) is a potent and selective PARP-inhibitor with Ki values of 5.2 nM and 2.9 nM for PARP-1 and PARP-2, respectively.1 Restores...
$50.00 – $140.00
Verrucarin A (3148-09-2) is a macrocyclic trichothecene mycotoxin from Myrothecium sp. It is a potent and selective inhibitor of the steroid recept...
$130.00
Stavudine (3056-17-5) is a thymidine derivative that acts as an HIV nucleoside reverse transcriptase inhibitor (NRTI) (EC50 = 8.8 nM for HIV-1 repl...
$52.00 – $170.00
MBQ-167 (2097938-73-1) is a dual inhibitor of the Rho GTPases Rac (IC50 = 103 nM) and Cdc42 (IC50 = 78 nM).1 It inhibits breast cancer cell migrat...
$75.00 – $265.00
JPH203 (1597402-27-1) is a selective L-type amino acid transporter 1 inhibitor (LAT1 or SLC7A5; IC50 = 140 nM for 14C-leucine uptake in S2-hLAT1 ce...
$85.00 – $295.00
SM-88 (30625-05-9) is a “dysfunctional” tyrosine mimetic. It is taken up by cancer cells and disrupts tyrosine-mediated metabolic pathways includin...
$40.00 – $125.00
V-9302 (1855871-76-9) is a selective inhibitor of the alanine-serine-cysteine transporter 2 (ASCT2 or SLC1A5; IC50 = 9.0 µM rat and 9.6 µM human).1...
$60.00 – $225.00
Nitisinone (104206-65-7) is an inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD; IC50 = 40 nM1 and 173 nM2) and is in clinical use for the tr...
$25.00 – $95.00
NG52 (212779-48-1) is an inhibitor of Cdc2-cyclin B (IC50 = 340 nM) as well as Cdc28p (IC50 = 7 µM) and Pho85p (IC50 = 2 µM).1 It inhibited phospho...
$80.00 – $295.00
Firsocostat (1434635-54-7) is a potent (IC50 = 1.7 nM ACC1; 2.6 nM ACC2) allosteric protein-protein interaction inhibitor of acetyl-CoA carboxylase...
$75.00 – $235.00
NDI-091143 (2375840-87-0) is a potent (IC50 = 2.1 nM ADP-Glo assay; 4.8 nM Oxaloacetate coupled enzyme assay) allosteric inhibitor of ATP-citrate l...
$60.00 – $220.00
A939572 (1032229-33-6) is a potent stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC50s = mouse: <4 nM, human: 37 nM).1 Active in various cancer mo...
$65.00 – $225.00
IM156 (1422365-93-2) is a potent activator of AMP-activated protein kinase (AMPK) showing greater activity than metformin or AICAR.1 It displayed p...
$60.00 – $195.00
Chroman 1 (1273579-40-0) is an extremely potent inhibitor of Rho kinase II (ROCK-II)1,2 – it displayed greater selectivity and potency compared to ...
$49.00 – $195.00
GSK126 (1346574-57-9) is a potent, selective, S-adenosyl-methionine-competitive inhibitor of EZH2 methyltransferase, Ki=0.5-3 nM, >150-fold sele...
$70.00 – $325.00
Calphostin C (121263-19-2) is a potent and specific inhibitor of protein kinase C (PKC, IC50 = 50 nM).1 Inhibition of PKC is light dependent2 and i...
$146.00 – $670.00
10074-G5 (413611-93-5) inhibits c-Myc by disrupting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity.1 10074-G5 binds to...
$55.00 – $170.00
Homoharringtonine (26833-87-3) is a plant alkaloid, originally isolated from the Hainan plum yew, that binds to the large ribosomal subunit A-site,...
$65.00 – $220.00
Mitapivat (1260075-17-9) is a potent (AC50 = 29 nM PKR; 37 nM PKM2; 33 nM PKL) allosteric activator of pyruvate kinase.1 In clinical use for the t...
$80.00 – $270.00
ABT-737 (852808-04-9) is an inhibitor of anti-apoptotic proteins from the Bcl family: Bcl-2, Bcl-X(L), and Bcl-w (Ki < 1 nM) that causes regress...
$80.00 – $245.00
Telaprevir (402957-28-2) is a Hepatitis C NS3/4A protease inhibitor that is in clinical use for genotype 1 infections (IC50 = 354 nM genotype 1b re...
$50.00 – $150.00
BZ1 (2766623-38-3) is a potent (Kd = 6.3 nM; IC50 = 67 nM BPTF Alphascreen) inhibitor of the bromodomain PHD finger transcription factor (BPTF). I...
$65.00 – $250.00
Ponasterone A (13408-56-5) is a potent ecdysone agonist which elicits molting and metamorphosis in insects.1 Ponasterone A and related ecdysteroids...
$50.00 – $200.00
CCG-4986 (7134-19-2) is the first selective non-peptide inhibitor of the regulator of G protein signaling protein subtype RGS4.1 It covalently2-3 m...
$60.00 – $220.00
CBR-470-1 (2416095-06-0) is an activator of NRF2 signaling (EC50 ~ 1 µM cellular ARE-LUC assay).1 It inhibits phosphoglycerate kinase 1 leading to ...
$80.00 – $295.00
Deucravacitinib (1609392-27-9) is very potent and selective allosteric inhibitor of tyrosine kinase 2 (TYK2). It binds to and is selective for the ...
$125.00 – $420.00
Honokiol (35354-74-6) is a natural product that acts as a SIRT3 activator. It increases mitochondrial oxygen consumption and reduces ROS production...
$55.00 – $220.00
CBL0137 (1197996-80-7) is an anticancer agent that activates p53 and suppresses NF-kB via trapping of the FACT (facilitates chromatin transcription...
$80.00 – $295.00
YM-58483 (223499-30-7) is a CRAC (calcium release-activated calcium) channel blocker1, a prototypic store-operated calcium channel2. Inhibits anti...
$80.00 – $310.00
Streptonigrin (3930-19-6) promotes heterochromatin formation at concentrations as low as 1 nM, a concentration at which there was no effect on prol...
$180.00
Spastazoline (2351882-11-4) in as ATP-competitive inhibitor (IC50 = 99 nM) of the microtubule-severing AAA protein spastin. It is selective agains...
$110.00 – $395.00
MGD·Na (91840-27-6) forms a stable and water soluble nitric oxide spin-trapping complex with Fe2+.1,2 A useful reagent for the measurement of nitri...
$50.00 – $160.00
GYY4137 (106740-09-4) is a water soluble hydrogen sulfide slow-releasing molecule.1 Rate of release at pH 7.4 and 37°C was 4.17 ± 0.5 nmol/25 min. ...
$45.00 – $165.00
NG-497 (2598242-66-9) is the first small molecule inhibitor (IC50 = 1 µM) of human (and rhesus monkey) adipose triglyceride lipase (ATGL). It is i...
$70.00 – $260.00
Emricasan (254750-02-2) is a liver-targeted antiapoptotic pan-caspase inhibitor.1,2 It has been investigated as a hepatoprotective agent in the tre...
$80.00 – $310.00
Cercosporin (35082-49-6) is a perylenequinone from the fungus Cercospora kikuchii. Upon photo- activation, perylenequinones display almost universa...
$60.00 – $240.00
FIN56 (1083162-61-1) is a novel inducer of ferroptosis acting via degradation of GPX4 and activation of squalene synthase (leading to CoQ10 depleti...
$65.00 – $235.00
Luminespib (747412-493) is a potent inhibitor (IC50 = 21 nM) of HSP90.1 It is active against various human tumor xenograft models acting via severa...
$45.00 – $145.00
Nocardamine (26605-16-3) is a bacterially produced siderophore1 which can act as an intracellular ion chelator2. A cyclic analog of the ferroptosi...
$125.00
C-DIM 8 (151358-47-3) is an antagonist of the orphan nuclear receptor Nur77 (NR4A1, TR3).1 Induces reactive oxygen species and ER stress in pancrea...
$40.00 – $150.00
VE-821 (1232410-49-9) is a potent and selective ATP-competitive ATR (Ataxia-telangiectasia and Rad3-related protein) inhibitor, Ki=13 nM.1 Increase...
$80.00 – $290.00
Tenovin-1 (380315-80-0) activates p53 via inhibition of SIRT1 and SIRT2.1,2 Induces apoptosis in a variety of cancer cell lines including cutaneous...
$40.00 – $125.00
SRS16-86 (1793052-96-6) is a third generation ferrostatin derivative with greater metabolic and plasma stability for in vivo studies. It protected ...
$69.00 – $219.00
RSL3 (1219810-16-8) Inhibits glutathione peroxidase (GPX4) inducing ferroptosis.1,2 Effectively induces ferroptosis in glioblastoma cells.3 Evero...
$85.00 – $250.00
Brigatinib (1197953-54-0) is a potent and selective pan-ALK inhibitor (IC50=0.6 nM).1 Cells with ALK mutation L1196Q2 and the double mutation I117...
$50.00 – $160.00
P7C3-A20 (1235481-90-9) is a neuroprotective and proneurogenic agent acting via NAMPT stimulation.1 Displays neuroprotective and promotes endogenou...
$60.00 – $240.00
EGA (415687-81-9) is a novel selective inhibitor of endosomal trafficking which blocks cellular entry of lethal toxin and other acid-dependent bact...
$60.00 – $230.00
Z-Leu-Arg-AMC (156192-32-4) is a sensitive Cathepsin K fluorogenic substrate (Km=8µM, kcat/Km=4 x 105 M-1s-1)1-3. It is cleaved more slowly by the ...
$80.00
Z-Phe-Arg-AMC (70382-26-2) is a fluorogenic substrate1 for the following cathepsins (kcat/Km in M-1s-1): B (105)2, C/DPP-I (104)3, F (106)4, K/O2 (...
$45.00
HA-100·2HCl (85568-24-6) inhibits the following kinases PKG (IC50=4 mM), PKA (IC50=8 mM), PKC (IC50=12 mM).1 Increases human fibroblast reprogramm...
$50.00 – $200.00
UNC7145 (2561494-78-6) is a negative control for UNC6934, an inhibitor of protein lysine methyltransferase nuclear receptor-binding SET domain-cont...
$70.00 – $275.00
SU0268 (2210228-45-6) is potent (IC50 = 59 nM) inhibitor of the DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1).1,2 Selective versus other DN...
$75.00 – $265.00
Deferasirox (201530-41-8) is a clinically useful iron chelator used in long term care of ß-thalassemia and other heavily transfused hematological p...
$50.00 – $135.00
TH1760 (2567914-01-4) is a potent inhibitor (IC50 = 25 nM dGTP hydrolysis; 57 nM 6-thio-dGTP hydrolysis) of the NUDIX hydrolase NUDT15, an importan...
$65.00 – $240.00
Cytochalasin B (14930-96-2) is a cell permeable fungal toxin which binds to the barbed end of actin, inhibiting its polymerization.1 Inhibits cell ...
$40.00 – $105.00
UNC6934 (2561494-77-5) is a potent (IC50 = 104 nM) and selective inhibitor of protein lysine methyltransferase nuclear receptor-binding SET domain-...
$70.00 – $260.00
CB-103 (218457-67-1) is an orally active inhibitor of the Notch signaling activation complex (IC50’s from 0.9 to 3.9 µM in various cell-based assay...
$40.00 – $95.00
Jun9-72-2 (CAS 2657659-42-0) is potent inhibitor (IC50 = 670 nM) of SARS-CoV2 papain-like (PL) protease. It showed potent antiviral activity in bo...
$75.00 – $275.00
Adavosertib (955365-80-7) inhibits Wee1 tyrosine kinase (IC50 = 5.2 nM) thus preventing phosphorylation of CDC2 and abrogating the G2 DNA damage ch...
$45.00 – $155.00
Sesamin (607-80-7) is a natural product derived from sesame seeds with anticancer1, antioxidant2, anti-inflammatory/immunomodulatory3, and antidiab...
$45.00 – $115.00
BX795 (702675-74-9), originally described as a moderately potent inhibitor of PDK1 (IC50 = 111 nM)1, is, more importantly, a dual inhibitor of TBK1...
$65.00 – $250.00
Aprepitant (170729-80-3) is a potent human neurokinin-1 (NK-1) antagonist.1 It is an FDA approved medication for the treatment of chemotherapy-ind...
$40.00 – $130.00
BI 749327 (2361241-23-6) is a potent (IC50 = 13 nM mouse TRPC6, 19 nM human TRPC6) and selective (85-fold over TRPC3, 42-fold over TRC7) orally ava...
$80.00 – $300.00
Bosutinib (380843-75-4) is an ATP-competitive dual Src/Abl kinase inhibitor (IC50 = 1 nM).1 It potently inhibits the apoptosis-linked STE20 kinase...
$40.00 – $140.00
PLX5622 (1303420-67-8) is a highly selective (>20 fold over KIT and FLT3, >60 fold over 200 other kinases) and brain-penetrant inhibitor of c...
$70.00 – $220.00
Vesatolimod (1228585-88-3) is a Toll-like receptor 7 (TLR7) agonist (EC50 = 290 nM in a HEK293 cell line reporter assay; IFNα MEC 3 nM, 100 fold se...
$45.00 – $150.00
Selonsertib (1448428-04-3) is a potent Apoptosis signal-regulating kinase 1 (ASK1) inhibitor (pIC50 = 8.3)1 found to improve metabolic parameters i...
$50.00 – $175.00
GSK6853 (1910124-24-1) is a very potent (pIC50 = 8.6 vs full length protein, 7.7 in cellular assays) inhibitor of Bromodomain and PHD Finger-contai...
$65.00 – $250.00
Rasarfin (674359-73-0) is a dual inhibitor of Ras and ARF6 discovered by screening a library of over 115,000 small molecules employing an endosomal...
$70.00 – $280.00
ICA-121431 (313254-51-2) is a selective Nav1.1/1.3 inhibitor (hIC50s = 23 and 13 nM respectively; also selective for dog, monkey, and mouse, but no...
$50.00 – $175.00
BAY-1797 (2055602-83-8) is a selective P2X4 receptor antagonist (IC50 = 211 nM HEK cellular assay; P2X4 calcium influx based assays – hIC50 = 108 n...
$75.00 – $325.00
A-438079 (899431-18-6) is a competitive P2X7 receptor antagonist (pIC50 = 6.9).1 Displayed antinociceptive effects in a rat model of neuropathic pa...
$60.00 – $225.00
PF-05089771 (1235403-62-9) is a potent and selective inhibitor of the voltage gated sodium channel 1.7 (Nav1.7).1,3 It is a state-dependent inhibi...
$60.00 – $240.00
1G244 (847928-32-9) is a potent and selective inhibitor of the prolyl dipeptidases DPP8 (IC50 = 14 nM) and DPP9 (IC50 = 53 nM).1,2 It does not inh...
$70.00 – $270.00
PNF1 (10442-95-2) is a novel small molecule inducer of angiogenesis which has been shown to be useful in tissue engineering applications.1 In a sus...
$70.00 – $280.00
AR7 (80306-38-3) is an atypical retinoid which acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pat...
$70.00 – $280.00
GW788388 (452342-67-5) is a potent inhibitor of TGF-β receptor kinases ALK4, ALK5 (IC50=18 nM), ALK7, and TGFβRII, but not BMP type II receptor kin...
$80.00 – $260.00
KNK437 (218924-25-5) Inhibits constitutive and inducible HSP70 expression in non-stressed1 and heat-stressed2 cancer cells. Blocks the geldanamycin...
$60.00 – $180.00
L6H21 binds to MD-2 (myeloid differentiation protein-2, Kd=33.3 µM) and blocks its interaction with TLR4 (toll-like receptor 4) in LPS-stimulated c...
$55.00 – $180.00
TPCA-1 (507475-17-4) selective inhibitor of IκB kinase 2 (IKK2) (IC50 = 17.9 nM).1 Inhibits production of pro-inflammatory cytokines in arthritis a...
$70.00 – $200.00
BTB-1 (86030-08-2) is a selective, ATP-competitive and reversible inhibitor of mitotic kinesin Kif18A, IC50=1.7 mM.1,2 Binds to an allosteric site...
$40.00 – $148.00
Sulfopin (2451481-08-4) is a potent and selective covalent inhibitor of peptidyl-prolyl isomerase NIMA interacting-1 (Pin1) (Ki = 17 nM).1 Although...
$40.00 – $125.00
SRT1720 (1001645-58-4) is a SIRT1 activator (EC1.5 = 0.16 µM, max activation = 781%).1 It reduced glucose levels and hyperinsulinemia in DIO, Lepob...
$75.00 – $325.00
Ki8751 (228559-41-9) is a very potent (IC50 = 0.9 nM) inhibitor of vascular endothelial growth factor receptor 2 (VEGFR-2).1 It also inhibited PDGF...
$39.00 – $150.00
GSK2656157 (1337532-29-2) is a potent (IC50 = 0.9 nM) and selective (over 300 kinases) inhibitor of protein kinase RNA-like endoplasmic reticulum k...
$40.00 – $160.00
Xanomeline tartrate (152854-19-8) functionally-selective M1 muscarinic receptor agonist, EC50=0.3, 92.5, 5, 52 and 42 nM for M1, M2, M3, M4 and M5 ...
$70.00 – $280.00
Liproxstatin-1 (950455-15-9) is an inhibitor of ferroptosis (IC50 = 22 nM).1 It was able to mitigate tissue injury in a mouse model of hepatic isch...
$65.00 – $250.00
GSK2982772 (1622848-92-3) is a highly selective inhibitor of Receptor-interacting Protein 1 kinase (RIP1); IC50 = 1.6 nM.1 Novel anti-inflammatory ...
$95.00 – $350.00
AS-1949490 (1203680-76-5) is a potent and selective inhibitor of the intracellular phosphatase SHIP2 (SH2 domain-containing inositol 5'-phosphatas...
$62.00 – $248.00
Extracts of Inula which contain tomentosin (33649-15-9) have been used for centuries in traditional medicine for the treatment of inflammation.1 It...
$75.00 – $300.00
SR-717 (2375421-09-1) is a cell permeable and exceptionally selective STING agonist (IC50 = 7.8 µM). It displayed robust antitumor activity in B16...
$80.00 – $275.00
MAC-545496 (838810-96-1) is an inhibitor of glycopeptide-resistance-associated protein R (GraR, also known as ApsR). GraR and its regulatory syste...
$60.00 – $195.00
ML300 is a selective non-covalent inhibitor of SARS-CoV 3CL protease (IC50 = 4.11 µM).1,2
References:
Turlington et al. (2012) Non-covalent...
$75.00 – $250.00
GS-441524 (1191237-69-0) is the parent nucleoside and active metabolite of the SARS-CoV2 drug remdesivir. Displayed broad spectrum antiviral activ...
$45.00 – $145.00
SX-682 is a novel CXCR1/2 inhibitor (IC50s: CXCR1 = 42 nM, CXCR2 = 20 nM).1 It displayed robust synergistic activity with immune checkpoint blockad...
$110.00 – $425.00
AE 51310 (433966-92-8) is a potent antagonist of the GPCR OPN4/melanopsin (Ki = 0.096 nM human OPN4).1 OPN4 regulates circadian rhythms, pupil func...
$50.00 – $195.00
Ipatasertib (1001264-89-6) is a selective (against a panel of 230 kinases) and potent pan-Akt inhibitor (IC50s: Akt1 = 5 nM, Akt2 = 18 nM, Akt3 = 8...
$65.00 – $240.00
BO-264 (2408648-20-2) is a potent (IC50 = 188 nM) inhibitor of transforming acidic coiled-coil 3 (TACC3), an important protein involved in microtub...
$65.00 – $240.00
GPR84 is an orphan G protein-coupled receptor that is activated by medium-chain fatty acids and hydroxy fatty acids although these may not be its e...
$60.00 – $220.00
IM-12 (1129669-05-1) is a potent and selective inhibitor of glycogen synthase kinase 3ß (GSK-3ß) IC50=53 nM which induces neuronal differentiation...
$52.00 – $176.00
Locostatin (133812-16-5) inhibits cell migration by disrupting the interaction between Raf kinase inhibitor protein (RKIP) and Raf-1 kinase.1 Locos...
$48.00 – $135.00
Cepharanthine (481-49-2) is a naturally occurring alkaloid from Stephania cepharantha Hayata which possesses a number of pharmacological activitie...
$35.00 – $140.00
Velpatasvir (1377049-84-7) is an extremely potent pan-genotypic hepatitis C virus (HCV) NS5A inhibitor.1 It is a component of Epclusa® and Vosevi®,...
$40.00 – $125.00
Darunavir (206361-99-1) is a very potent (IC50 = 3 nM against lab HIV-1 strains and clinical isolates) HIV-1 protease inhibitor that is in clinical...
$60.00 – $200.00
R-59022 (93076-89-2) is a diacylglycerol kinase (DAGK) inhibitor, nonselective for DAGK isotypes (IC50=2.8 µM in intact platelets).1 Induces autoph...
$70.00 – $270.00
Canagliflozin (842133-18-0) is a potent inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), IC50 = 2.2 nM, selective over SGLT1, IC5...
$50.00 – $160.00
2-AAPA (1133387-90-2) inhibits glutathione reductase and thioredoxin reductase,IC50s=6.7 and 8.7 µM respectively, and impairs mitochondrial functio...
$60.00 – $240.00
Cedrol is a sesquiterpene alcohol found in conifers mainly of the genera Cupressus, Juniperus, and Cedrus. It has been found to possess significant...
$30.00 – $80.00
LNT 1 (824983-91-7) is a potent (IC50 = 11 nM) inhibitor of flap endonuclease 1 (FEN1).1 It showed similar potency in inhibiting exonuclease 1 (EXO...
$70.00 – $230.00
TTA-P2 (918430-49-6) is a potent (IC50 = 100 nM), specific, and reversible antagonist of T-type calcium channels with no activity at high voltage c...
$50.00 – $175.00
Saracatinib (379231-04-6) is a potent and selective inhibitor of Src family kinases, IC50=4-10 nM for Src, c-Yes, Fyn, Lyn, Blk, Fgr and Lck.1 Demo...
$40.00 – $145.00
Chromomycin A3 (7059-24-7) is a DNA-binding agent specific for GC-rich sequences1 which may be used as a DNA stain2. Inhibits neuronal apoptosis in...
$52.00 – $150.00
Filgotinib (1206161-97-8) is a potent and selective JAK1 inhibitor (IC50s=10, 28, 810 and 116 nM for JAK1, JAK2, JAK3 and TYK2 respectively).2 Dis...
$65.00 – $220.00
NQDI-1 (175026-96-7) is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), Ki = 500 nM.1 Promotes survival of induced...
$65.00 – $250.00
SB-705498 (501951-42-4) is a potent and selective blocker of the TRPV1 receptor (IC50’s for receptor induction method: Capsaicin = 3 nM; Acid (pH5....
$70.00 – $240.00
Readily oxidized in vivo to free radical forms, which destroy the stable tyrosyl free radical of the metalloenzyme ribonucleotide reductase, suppre...
$54.00 – $185.00
SM-164 (957135-43-2) is a cell-permeable Smac (DIABLO) mimetic that inhibits caspase blockers XIAP, cIAP1, and cIAP2 (Ki = 36, <1, and <1.9 n...
$190.00 – $400.00
Pyridone 6 (457081-03-7) is a potent, ATP-competitive pan-JAK inhibitor. Inhibits 1, 2 and 3 (IC50=1, 5 and 15 nM respectively) as well as JAK fami...
$60.00 – $116.00
Belumosudil (911417-87-3) is a selective inhibitor of Rho kinase 2 (ROCK2) – IC50’s: ROCK2 = 105 nM, ROCK1 = 24 µM in enzyme assays.1 It downregula...
$45.00 – $145.00
Gilteritinib (1254053-43-4) is a potent inhibitor of FLT3 (IC50 = 5 nM, wild-type FLT3) with more potent activity against all FLT3 mutants.1 It als...
$70.00 – $250.00
C6-NBD Ceramide (94855-02-6) is a selective stain for the Golgi apparatus.1 Readily taken up by MDCK cells and converted into C6-NBD-sphingomyelin ...
$100.00 – $400.00
Fulvestrant (129453-61-8) is a 17β-estradiol analog that acts as an estrogen receptor (ER) antagonist and GPR30/GPER agonist with high binding affi...
$62.00 – $165.00
CR8 (294646-77-8) is a second generation analog of roscovitine which inhibits cyclin-dependent kinases with increased potency, Cdk1/cyclin B, Cdk2/...
$110.00 – $440.00
GAC Inhibitor 968 (311795-38-7) is an allosteric inhibitor of glutaminase C (GAC).1 Inhibition of GAC blocks oncogenic transformation induced by Rh...
$50.00 – $200.00
Gliotoxin (67-99-2) is a fungal metabolite with immunosuppressive properties; blocks phagocytosis, cytokine production and proliferation of T and B...
$85.00 – $340.00
Isopimaric acid (5835-26-7) is a terpenoid acid that activates BK (voltage-gated potassium) channels when used at 10 µM in HEK293 cells.1 Improves ...
$60.00 – $240.00
SGI-1027 (1020149-73-8) is a potent and selective inhibitor of DNA methyl transferase inhibiting DNMT1, DNMT3A and DNMT3B with comparable potency (...
$70.00 – $280.00
5-Thio-D-glucose (20408-97-3) is a potent competitive inhibitor of the cellular transport of glucose and glucose-mediated insulin release.1 May be ...
$80.00 – $320.00
A nitric oxide (NO) scavenger. Carboxy-PTIO (148819-94-7) reacts with NO with 1:1 stoichiometry1 producing NO2-/NO3-. In LPS-induced endotoxin s...
$48.00 – $160.00
GPR142 is highly expressed in the pancreas and immune system and shares 33% homology with GPR139.1 Endogenous agonists identified to date include a...
$65.00 – $260.00
RITA (reactivation of p53 and induction of tumor cell apoptosis, 213261-59-7) binds to p53 (Kd = 1.5 nM), changing its conformation, preventing it ...
$70.00 – $300.00
EHNA (51350-19-7) inhibits phosphodiesterase 2 (PDE2) (IC50 = 0.8 – 5.5 µM in a variety of tissues and species) over PDE1, PDE3, or PDE4 (IC50 valu...
$60.00 – $240.00
SKA-31 (40172-65-4) is a KCa3.1 and KCa2 potassium channel activator (EC50 =260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Enhance...
$60.00 – $200.00
Biotin-isoxazole (1377605-22-5) precipitates hundreds of RNA-binding proteins with significant overlap to the constituents of RNA granules.1,2 In o...
$100.00 – $360.00
Apilimod (541550-19-0) is a potent (IC50 = 10 nM IFN-g/LPS-stimulated human PMBC’s; IC50 = 1 nM in IFN-g/SAC-stimulated human PMBC’s) IL-12/IL-23 i...
$45.00 – $160.00
Metolazone (17560-51-9) activates mitochondrial unfolded protein response (UPRMT) and -increases C. elegans lifespan.4 Clinically useful diuretic t...
$50.00 – $200.00
The ß-cyclodextrin complex of Mitoquinone mesylate is an easier to use, less deliquescent form of the useful mitochondrial antioxidant Mitoquinone....
$80.00 – $280.00
PFI-3 (1819363-80-8) is a selective inhibitor of family VIII bromodomains PB1(5), SMARCA2, and SMARCA4.1 It showed complete selectivity over all no...
$59.00 – $215.00
JQ1 (+) (1268524-70-4) is a potent BET bromodomain inhibitor and is the active isomer. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2...
$100.00 – $400.00
Ceapin-A7 (2323027-38-7) is a selective inhibitor (IC50 = 590 nM) of transcription factor ATF6α, one of the three branches of the unfolded protein ...
$75.00 – $295.00
Saxagliptin (709031-78-7) is a clinically useful DPPIV inhibitor for the treatment of diabetes.1 Human DPP-IV Ki = 0.6 nM.2
References:
Ta...
$39.00 – $140.00
Belnacasan (273404-37-8) is a prodrug of VRT-043198, a potent (Ki = 0.8 nM ICE/caspase-1; <0.6nM caspase-4) and selective inhibitor of interleuk...
$45.00 – $160.00
Enzalutamide (915087-33-1) is a clinically useful non-steroidal antiandrogen (IC50 = 36 nM) for the treatment of castration-resistant prostate canc...
$50.00 – $175.00
WP631 is a novel bisintercalating anthracycline. Potent inhibitor of Sp1-activated transcription.1,2 Induces caspase-dependent apoptosis in human o...
$65.00 – $270.00
CCT251236 (1693731-40-6) is an inhibitor of the Heat Shock Transcription Factor 1 (HSF1) stress pathway (IC50 = 19 nM Inhibition HSF-1 mediated HSP...
$90.00 – $325.00
AZD-2098 (566203-88-1) is a potent, orally bioavailable antagonist of CCR4 (pIC50 = 7.8(h), 8.0(r), 8.0(m), 7.6(d)).1 Inactive at CXCR1/2, CCR1, CC...
$50.00 – $185.00
PTC-209 (315704-66-6) is an inhibitor of BMI-1 (IC50 = 500 nM), part of the polycomb repressive complex 1 (PRC1).1 It inhibited endogenous BMI-1 e...
$65.00 – $240.00
PB28 (172907-03-8) is a very potent high affinity (Ki = 5.3 nM1, 0.34 nM2) σ2 agonist. Selective for σ2 over σ1 (approx 30-40x).1,2 PB28 inhibited...
$45.00 – $160.00
Thiolutin (87-11-6) inhibits the deubiquitinating (DUB) activity of PSMD14 exhibiting potent antitumor activity in neck squamous cell carcinoma in ...
$60.00 – $186.00
MDL-800 (2275619-53-7) is an allosteric activator of SIRT6 (EC50 = 10.3 µM).1 It specifically activates the deacetylase (H3K9ac and H3K56ac) activi...
$85.00 – $315.00
Buparlisib (944396-07-0) is potent pan-Class I PI3-kinase inhibitor (IC50’s: p110α = 52 nM, p110ß = 166 nM, p110δ = 116 nM. P110g = 262 nM).1,2 It ...
$70.00 – $265.00
Autogramin-2 (2375541-45-8) is an inhibitor of autophagy (autophagy induced by amino acid starvation IC50 = 270 nM; Rapamycin IC50 = 140 nM) acting...
$70.00 – $275.00
Ganetespib (888216-25-9) is an inhibitor of heat shock protein 90 (IC50 = 19 nM, canine C2 malignant mast cells; 4 nM, canine BR malignant mast cel...
$65.00 – $250.00
CDN1163 (892711-75-0) is an allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA).1,2 It lowered fasting glucose levels, imp...
$55.00 – $185.00
BIIB021 is a potent HSP90 inhibitor (IC50 = 30 nM HER-2 degradation).1 It inhibited the proliferation of MCF7 and BT474 breast cancer cell lines (I...
$50.00 – $175.00
Glumetinib (1642581-63-2) is a highly selective (2400-fold selectivity against a panel of 312 kinases) and potent (IC50 = 0.42 nM) inhibitor of c-M...
$90.00 – $325.00
GSK8612 (2361659-62-1) is a highly selective and potent (avg. pIC50 = 6.8 versus recombinant TBK1) inhibitor of Tank-binding Kinase-1 (TBK1) with h...
$95.00 – $370.00
NVP-231 (362003-83-6) is a reversible inhibitor of ceramide kinase (IC50 = 12 nM).1 At 10 nM, it inhibited ceramide-1-phosphate formation by >50...
$40.00 – $130.00
PBD-150 (790663-33-1) is an inhibitor of human glutaminyl cyclase (IC50 = 60 nM).1 PBD-150 diminished Ab plaque formation and gliosis while improvi...
$60.00 – $225.00
TASIN-1 (1678515-13-3) selectively induces apoptosis in cells with truncations in the adenomatous polyposis coli (APC) gene (but not normal cells o...
$70.00 – $275.00
GRL-0667 (1234195-91-5) is a potent (IC50 = 320 nM) noncovalent inhibitor of severe acute respiratory syndrome-coronavirus papain-like protease (SA...
$95.00 – $370.00
Bepridil (74764-40-2) is a clinically useful calcium channel blocker with antianginal activity.1 It has recently been shown to possess potent activ...
$40.00 – $125.00
DAPI (28718-90-3) is a fluorescent DNA stain for use on fixed cells for applications such as imaging, mitochondrial DNA detection1, or nuclear quan...
$45.00 – $150.00
Isohelenin (470-17-7) is a sesquiterpene lactone isolated from Mexican Indian medicinal plants known to have anti-inflammatory properties. A potent...
$50.00 – $180.00
CID1067700 (314042-01-8) is a specific competitive inhibitor of nucleotide binding to Rab7, an endosome-localized small GTPase.1 It interferes with...
$65.00 – $240.00
PI-103 (371935-74-9) is a potent inhibitor of PI-3 kinase, mTOR and DNA-PK, IC50 = 8, 88, 150, 48, 20, 83 and 2 nM for p110α, p110ß, p110γ, p110δ,...
$60.00 – $240.00
RU.521 (2262452-06-0) is an inhibitor of cyclic GMP-AMP synthase (cGAS), an important innate immune system sensor of foreign cytoplasmic double-str...
$95.00 – $325.00
ABX-1431 (1446817-84-0) is a potent (IC50 = 14 nM in vitro, 2.2 nM in human PC3 cells) and very selective (>100-fold over hABHD6, >200-fold o...
$60.00 – $235.00
Flumazenil (78755-81-4) is a benzodiazepine antagonist1, panspecific for α1, α2, α3 or α5-containing GABAA receptors2. Reduces withdrawal sequelae...
$50.00 – $200.00
Verteporfin (129497-78-5) inhibits transcription by YAP/TAZ, IC50 = 2.5 µM, (via disruption of YAP-TEAD interaction) inhibiting autophagy and halti...
$75.00 – $300.00
DJ001 (2161306-12-8) is a potent and specific inhibitor of receptor type protein tyrosine phosphatase-sigma (PTPσ) IC50=1.54 µM and >10 µM for 2...
$70.00 – $300.00
KL101 (396721-89-4) is an isoform-selective stabilizer of the circadian clock protein CRY1. It dose-dependently lengthened the circadian period in...
$80.00 – $305.00
TH301 (450338-32-6) is an isoform-selective stabilizer of the circadian clock protein CRY2. It dose-dependently lengthened the circadian period in...
$80.00 – $325.00
Mitoquinone mesylate (845959-50-4) is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.1 Displays beneficial effe...
$70.00 – $240.00
Picotamide (32828-81-2) is an antiplatelet agent that inhibits both thromboxane A2 and thromboxane A2 synthase.1-3
References/Citations:
Mo...
$75.00 – $295.00
Torin1 (1222998-36-8) is a potent and selective ATP-competitive mTOR inhibitor, IC50=2 and 10 nM for mTORC1 and mTORC2 respectively.1,2 Active in v...
$70.00 – $280.00
URMC-099 (1229582-33-5) is a potent (IC50 = 14 nM), brain penetrant mixed-lineage kinase 3 inhibitor (MLK3). It also potently inhibits FLT3 (4 nM i...
$55.00 – $190.00
Guggulsterone-(Z) (39025-23-5) is a natural steroid from Commiphora mukul extract (guggulipid) which lowers cholesterol and acts as an FXR antagoni...
$76.00 – $300.00
Remodelin (949912-58-7) is a potent and selective inhibitor of N-acetyltransferase 10 (NAT10) which is capable of acetylating microtubules and hist...
$65.00 – $280.00
TIC10 (1616632-77-9) is novel anti-cancer compound that acts via early-stage integrated stress response activation leading to selective cancer cell...
$50.00 – $195.00
GKT-137831 (1218942-37-0) is an NADPH oxidase, NOX1/4 inhibitor (Ki = 100-150 nM).1 Inhibits erastin-stimulated ROS production.2 Potentiates immun...
$70.00 – $280.00
Ritonavir (155213-67-5) is a clinically useful HIV-1/HIV-2 protease inhibitor.1 Potent inhibitor of cytochrome P450 3A4.2,3
References/Citations...
$40.00 – $150.00
Oseltamivir phosphate (204255-11-9) is a potent viral neuraminidase inhibitor and a clinically useful treatment for influenzas A and B.1,2 Oseltami...
$30.00 – $110.00
Tiagabine (145821-59-6) is a clinically useful anticonvulsant.1 It is also used to treat anxiety/panic disorder2 and neuropathic pain3. Tiagabine i...
$35.00 – $125.00
GRL-0617 (1093070-16-6) is a potent (IC50 = 600 nM) noncovalent inhibitor of severe acute respiratory syndrome-coronavirus papain-like protease (SA...
$75.00 – $250.00
Nelfinavir mesylate (159989-65-8) is a clinically useful anti-HIV agent acting via inhibition of HIV-1 protease (Ki=2 nM).1 It also displays effica...
$60.00 – $210.00
Prochlorperazine maleate (84-02-6) inhibits dynamin and clathrin-mediated endocytosis (CME) with an IC50=5.8 µM for CME.1 Increases tumor cell anti...
$180.00 – $550.00
Favipiravir (259793-96-9) is an inhibitor of Influenza viruses A, B, and C (IC50’s: A = 0.03-0.20 µg/mL H1N1, 0.01-0.30 H2N2, 0.08-0.48 H3N2, 0.14-...
$45.00 – $160.00
Ponatinib (943319-70-8) is a highly potent pan-Bcr-Abl and multikinase inhibitor, suppressing the activity of native Bcr-Abl (IC50=0.37 nM) as well...
$50.00 – $170.00
Tazemetostat (1403254-99-8) is a potent (Ki = 2.5nM wild type human PRC2-containing) and selective SAM-competitive inhibitor of the lysine methyltr...
$55.00 – $175.00
GRL-0496 (1087243-14-8) is a potent (IC50 = 30 nM in cell culture assays) inhibitor of severe acute respiratory syndrome-coronavirus chymotrypsin-l...
$60.00 – $225.00
Roxatidine (78273-80-0) is a novel histamine H2 receptor antagonist.1 Suppresses inflammatory responses via inhibition of NFκB and p38 MAPK activat...
$90.00 – $360.00
Brequinar sodium (96201-88-6) is an inhibitor of dihydroorotate dehydrogenase (DHODH)1,2 with IC50’s between 0.2 and 5.8 µM in various cell lines3 ...
$70.00 – $275.00
Dihydroresveratrol (58436-28-5) is a metabolite of resveratrol produced by gut microbiota.1-3 Glucoronide conjugates are found in human urine after...
$50.00 – $170.00
Scriptaid (287383-59-9) inhibits histone deacetylases (HDAC) 1 and 3 (IC50~0.6 μM) and HDAC8 (IC50~1 μM) and is less toxic compared to trichostatin...
$75.00 – $270.00
N4-Hydroxycytidine (3258-02-4) was originally identified as a mutagen effecting AT to GC base-pair transitions.1 It has also been found to have ant...
$70.00 – $250.00
Camostat mesilate (59721-29-8) is a serine protease inhibitor inhibiting plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancrea...
$40.00 – $125.00
PK150 (2165324-62-7) is a Sorafenib analog that displays significant antibacterial activity against several pathogenic strains (S.aureus NCTC8325, ...
$55.00 – $195.00
DY131 (95167-41-2) is a selective agonist at estrogen-related receptors ERRβ and ERRγ with minimal activity at ERRα, ERα and ERβ at concentrations ...
$42.00 – $180.00
Leelamine HCl (16496-99-4) is a lysosomotropic, intracellular cholesterol transport inhibitor with potential chemotherapeutic activity. Induces cho...
$50.00 – $200.00
Santacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca...
$40.00 – $160.00
Fruquintinib (1194506-26-7) is a potent and highly selective inhibitor of VEGFR kinase (IC50’s: VEGFR1= 33 nM, VEGFR2 = 35 nM, VEGFR3 = 0.5 nM).1 I...
$75.00 – $255.00
AZ20 (1233339-22-4) is a potent and highly selective inhibitor of Ataxia telangiectasia mutated and RAD3-related (ATR) kinase (IC50 = 5 nM in vitro...
$60.00 – $200.00
AZD1152-HQPA (722544-51-6) is a potent and highly selective inhibitor of Aurora B.1 Aurora B Ki = 0.36 nM; Aurora A Ki = 1,369 nM.2 It inhibits the...
$50.00 – $150.00
Lomeguatrib (192441-08-0) is a potent (IC50 = 9 nM) inhibitor of O6-Methylguanine-DNA Methyltransferase (MGMT), an important DNA repair protein.1 I...
$50.00 – $195.00
Levetiracetam (102767-28-2) is a clinically useful non-classical anticonvulsant.1 It has no effect on voltage-dependent Na+ channels, GABAergic tra...
$45.00 – $70.00
Tigecycline (220620-09-7) is a clinically useful antibiotic.1,2 It is a glycylcycline derivative of minocycline that binds to the 30S ribosomal sub...
$50.00 – $195.00
Volasertib (755038-65-4) is an extremely potent and selective inhibitor (IC50’s: Plk1= 0.87 nM, Plk2 = 5 nM, Plk3 = 56 nM) of Polo-like kinase 1, a...
$80.00 – $275.00
SNS-314 mesylate (1146618-41-8) is a potent and selective pan-Aurora kinase inhibitor (IC50’s: Aurora A = 9 nM, Aurora B = 31 nM, Aurora C = 3 nM)....
$70.00 – $250.00
Elafibranor (923978-27-2) is a dual PPARα/δ agonist (EC50 PPARα = 10-20 nM; PPARδ = 100-150 nM).1 It was able to decrease plasma triglycerides leve...
$65.00 – $235.00
Methoprene Acid (53093-52-7) is an analog of insect juvenile hormone which acts as an insect growth regulator. Binds directly and selectively to th...
$70.00 – $280.00
NU7441 (503468-95-9) is a potent (IC50 = 13 nM) and selective ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK).1,2 It increased t...
$50.00 – $175.00
AZD7762 (860352-01-8, free base) is a potent and selective inhibitor of checkpoint kinases 1 and 2 (IC50 = 5 nM for both).1 It abrogates DNA damage...
$60.00 – $200.00
AZ3146 (1124329-14-1) is a potent (IC50 = 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor.1 Mps1 has an essential role in the ...
$60.00 – $195.00
NOTUM is a carboxylesterase which depalmitoylates Wnt proteins which results in disruption of Wnt signaling.1 NOTUMib-1 inhibits the carboxylestera...
$55.00 – $220.00
MitoBloCK-12 (522-51-0) attenuates mitochondrial protein import (4-10 μM). Discovered in a screen of FDA-approved drugs. Blocks translocation of a ...
$40.00 – $130.00
Two-pore domain potassium (K2P) channels of the TREK subfamily regulate neuronal excitability, influence pain, temperature perception and responses...
$55.00 – $220.00
DO264 (2301866-59-9) is a potent, reversible competitive inhibitor of ABHD12 (α/β-hydrolase domain-containing 12) which shows negligible interactio...
$70.00 – $280.00
N-Eicosanoyl serotonin is a natural product found in coffee which synergizes with caffeine in protecting the brain in models of α-synucleinopathy.1...
$50.00 – $180.00
Pomalidomide (19171-19-8) is a thalidomide analog that inhibits cereblon (CRBN), an E3 ubiquitin ligase, IC50 ~3 μM for CRBN-DDB1 complex.1 Display...
$50.00 – $150.00
Acalabrutinib (1420477-60-6) is a highly selective, potent (IC50 = 3 nM), and irreversible inhibitor of Bruton’s tyrosine kinase (BTK).1 Improved t...
$45.00 – $145.00
Norfluoxetine HCl (57226-68-3) is a metabolite of fluoxetine.3 Induces long QT syndrome via slow delayed rectifier potassium current block.1 Time d...
$60.00 – $200.00
Imiquimod (99011-02-6) is a Toll-like receptor 7/8 agonist with anti-viral and anti-tumor properties.1 Enhances innate immune system leading to Th1...
$30.00 – $75.00
Rucaparib phosphate (459868-92-9) is a potent (Ki<5 nM) PARP1 inhibitor.1 Cytotoxic to human cancer cells or xenograft tumors with mutated or ep...
$70.00 – $280.00
Ibrutinib (936563-96-1) is a very potent (IC50 = 0.5nM) irreversible inhibitor of Bruton tyrosine kinase (BTK) that blocks activation of the B-cell...
$40.00 – $125.00
BI 2536 (755038-02-9) was originally reported as a potent (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM)1 and selective2 Polo-like kinase in...
$75.00 – $275.00
Resiniferatoxin (57444-62-9) is an ultrapotent TRPV1 activator (Ki=43 pM).1 Resiniferatoxin is 100-10,000 fold more potent than capsaicin for most ...
$115.00 – $440.00
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