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5-Fluorouracil | Inhibitor of thymidylate synthase

5-Fluorouracil (51-21-8) is a clinically useful anticancer agent that acts via irreversible inhibition of thymidylate synthase. The active metabolites of 5-Fluorouracil are 5-Fluorodeoxyuridylate (5-FdUMP), 5-Fluorodeoxyuridine triphosphate (5-FdUTP) and 5-Fluorouridine triphosphate (5-FUTP). The primary cytotoxic effect of 5-Fluorouracil is believed to be inhibition of thymidylate synthase by 5-FdUMP. Secondary effects include incorporation of 5-FdUTP into DNA resulting in DNA strand breaks and incorporation of 5-FUTP into RNA causing abnormal RNA processing.1

References/Citations
1) Schlisky (1998), Biochemical and Clinical Pharmacology of 5-Fluorouracil; Oncology, 12 13

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Focus Biomolecules cell signaling tech supplier, structure 5-Fluorouracil | Inhibitor of thymidylate synthase | CAS 51-21-8

Catalog#  10-1276

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CAS:
51-21-8
Catalog Number:
10-1276
Activity:
Inhibitor of thymidylate synthase
Alternate Names:
5-FU
Chemical Name:
5-Fluoro-1H,3H-pyrimidine-2,4-dione
Molecular Weight:
130.08
Molecular Formula:
C4H3FN2O2
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98%
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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