Chemical Libraries

Targeted chemical libraries are important tools in the quest to understand cellular signaling in biological systems and how these pathways affect human health. Focus Biomolecules is creating intelligently designed libraries that seek to maximize the research potential of the included compounds while minimizing cost as well as waste and excess data created from having too large a library with superfluous and promiscuous compounds. Our libraries are curated to include the newest, most potent and selective, and importantly, relevant small molecule compounds for each pathway. IntelliScreen™ libraries are updated by the addition of new compounds on a regular basis.

LIBRARIES

10-7001 | Intelliscreen™ Highly-Selective Kinase Inhibitor Library

The IntelliScreen™ Highly Selective Kinase Inhibitor Library represents a targeted collection of compounds chosen for their specificity. Notorious for their lack of specificity, some of the oldest and most familiar inhibitors are among the most indiscriminate, inhibiting an array of kinases from multiple kinase families. While occasionally this promiscuity can be beneficial in biological applications, it tends to be an obstacle in pathway or target identification. This library is designed to offer researchers a compact collection of inhibitors deliberately chosen for their high selectivity for an individual target. This high degree of selectivity increases reliability, reduces ambiguity, and helps to limit the amount of additional testing required after screening.

10-7101 | Intelliscreen™ Cancer Cell Metabolism Library

The IntelliScreen™ Cancer Cell Metabolism Library was designed in conjunction with researchers at the Fox Chase Cancer Center (FCCC) in Philadelphia. The library contains over 170 modulators of all aspects of cellular metabolism which can be used to study the relationship between metabolic systems, cellular function, and the initiation, propagation, and spread of cancer. Metabolic pathways modulated by compounds in this library include: Glucose metabolism, glycosylation/deglycosylation, amino acid biosynthesis/transport, phosphorylation, glutathione homeostasis, bioactive lipid signaling/biosynthesis, nucleotide biosynthesis, and mitochondria function.

MINI-LIBRARIES

10-7315 | Intelliscreen™ Polycomb Repressive Complex Inhibitors Mini-Library

The polycomb-group proteins consist of two classes: Polycomb repressive complex 1 (PRC1) and polycomb repressive complex 2 (PRC2). PRC1 acts as a histone methyltransferase primarily methylating H3K27me3 while PRC2 is a histone ubiquitin ligase acting on histone H2A. Both have important roles in epigenetic gene regulation and are implicated in various disease states because of their role in cellular proliferation-differentiation balance, metabolism, and the immune response.

10-7305 | Intelliscreen™ Wnt/β-catenin (canonical) Mini-Library

The Wnt/ß-catenin pathway is a multi-component pathway primarily involved in embryonic development, adult tissue homeostasis, and cell proliferation. Wnt proteins (i.e Wnt1, Wnt3a, Wnt5a) mediate extracellular signals that activate Wnt membrane receptors Frizzled and LRP5/6. Once activated, these signals inactivate a ß-catenin degradation complex allowing ß-catenin to translocate to the nucleus where it binds to TCF enabling target gene transcription

10-7320 | Intelliscreen™ Protein Kinase C Mini-Library

The Protein kinase C family of serine/threonine kinases is involved in many cellular processes including gene transcription, cell growth and proliferation, membrane structure, and various immune responses. The Intelliscreen^TM Protein kinase C mini-library contains selective and pan-inhibitors of family.

10-7310 | Intelliscreen™ Neuropathic Pain Ion Channel Mini-Library

Neuropathic pain is caused by damage or dysfunction to peripheral or central nervous system nerve fibers and is frequently chronic in nature. Persistent increased excitability and spontaneous activity in neurons leads to chronic pain that is difficult to treat.

10-7325 | Intelliscreen™ Cholesterol Metabolites Mini-Library

Cholesterol is the primary sterol in all eukaryotes and is the precursor to bile acids, steroid hormones, vitamin D, and other important biomolecules.

10-7330 | Intelliscreen™ DNA Damage Inducers Mini-Library

DNA damage-inducing agents have been a cornerstone of cancer treatment for decades. DNA damage of cancer cells can lead to inhibition of cellular proliferation and induction of cell death.

10-7335 | Intelliscreen™ Immunoregulatory Kinases Mini-Library

T cells, B cells, and innate immune system cells express cytokine and immune recognition receptors that are activated directly by kinase phosphorylation or adaptor molecules affected by kinases.

10-7340 | Intelliscreen™ Protease Inhibitors Mini-Library

The Intelliscreen^TM Protease inhibitor mini-library is a useful screening tool for determining protease family involvement during proteolysis. The inhibitors have been selected to cover the most common protease families involved in degradation and / or processing, including aspartic, cysteine, serine, etc. peptidases; caspases; proteasome; metalloproteases; aminopeptidases, secretases, and signal peptide peptidases; and more.

10-7345 | Intelliscreen™ PI3K Inhibitors Mini-Library

Phosphatidylinositol 3-kinases (PI3K) are a family of lipid kinases that regulate various cellular processes including DNA repair, cell cycle, metabolism, senescence, and cell death. Aberrant PI3K function is implicated in a significant percentage of human cancers.

We will be continually expanding our offering of libraries and mini-libraries moving forward and we welcome your suggestions for additional pathways and categories.