Bafilomycin A1 (88899-55-2) is a macrolide antibiotic derived from Streptomyces griseus that is a potent and selective inhibitor of vacuolar H⁺-ATPases (IC₅₀ = 0.6 – 1.5 nM).^1,2 Bafilomycin A1 inhibits autophagy via disruption of fusion between autophagosomes and lysosomes.³

References/Citations

1) Werner et al.  (1984) Metabolic products of microorganisms. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity; J. Antibiot., 37 110
2) Drose and Altendorf  (1997) Bafilomycins and concanamycins as inhibitors of V-ATPase and P-ATPase; J. Exp. Biol., 200 1 
3) Yamamoto et al. (1998) Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells; Cell Struct. Func., 23 33