Bafilomycin A1 | Vacuolar H+ ATPase inhibitor

Bafilomycin A1 (88899-55-2) is a macrolide antibiotic derived from Streptomyces griseus that is a potent and selective inhibitor of vacuolar H+-ATPases (IC50 = 0.6 – 1.5 nM).1,2 Bafilomycin A1 inhibits autophagy via disruption of fusion between autophagosomes and lysosomes.3

References/Citations

1) Werner et al.  (1984) Metabolic products of microorganisms. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity; J. Antibiot., 37 110
2) Drose and Altendorf  (1997) Bafilomycins and concanamycins as inhibitors of V-ATPase and P-ATPase; J. Exp. Biol., 200 1
3) Yamamoto et al. (1998) Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells; Cell Struct. Func., 23 33

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size :

100 ug, 1 mg

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CAS:
88899-55-2
Catalog Number:
10-2060
Activity:
Vascular H+-ATPase inhibitor
Molecular Weight:
622.84
Molecular Formula:
C35H58O9
Solubility:
Soluble in DMSO (up to 5 mg/ml, with warming).
Physical Properties:
Off-white or yellow film
Purity:
95% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Bafilomycin A1 | Vacuolar H+ ATPase inhibitor

$40.00$160.00

CAS:
88899-55-2
Catalog Number:
10-2060
Activity:
Vascular H+-ATPase inhibitor
Molecular Weight:
622.84
Molecular Formula:
C35H58O9
Solubility:
Soluble in DMSO (up to 5 mg/ml, with warming).
Physical Properties:
Off-white or yellow film
Purity:
95% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
  • 100 ug
  • 1 mg
Clear
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