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  • 3-Methyladenine | Autophagosome inhibitor
    3-Methyladenine (5142-23-4) inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K)1,2. Protects 1321N1 astrocytoma cells against pyocyanin and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AICAR | AMPK activator | CAS 2627-69-2
    Activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor.1 Promotes skeletal muscle autophagy via activation of FoxO3a.2 Controls smooth muscle cell hyperproliferation in...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Apicidin | HDAC inhibitor | CAS 183506-66-3
    Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression...

  • Chloroquine phosphate | autophagy inhibitor
    Chloroquine phosphate (50-63-5) is an antimalarial drug. Inhibits autophagy in a variety of cell lines1. Induces cell death in breast cancer cell lines and displays antitumor and antimetastatic activity in mouse models of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Dorsomorphin | AMPK inhibitor | CAS 866405-64-3
    Dorsomorphin (866405-64-3) is a potent, selective and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM).1 It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. It inhibits bone...

  • Focus Biomolecules supplier, chemical structure of Hydroxychloroquine sulfate | Autophagy inhibitor | CAS 747-36-4
    Hydroxychloroquine sulfate (747-36-4) is a lysosomotropic agent which inhibits autophagy and triggers apoptosis in a variety of cell types.1,2 Augments the anticancer activity of DNA-damaging chemotherapy...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ISO-1 | MIF antagonist | CAS 478336-92-4
    ISO-1 (478336-92-4) is an antagonist of macrophage migration inhibitory factor (MIF, a pro-inflammatory cytokine). Displays anti-inflammatory activity. Increases survival in severe sepsis1. Inhibits airway remodeling in...

  • Manzamine A | Inhibitor of vacuolar ATPases
    Manzamine A (104196-68-1) inhibits vacuolar ATPases and inhibits autophagy in pancreatic cancer cells1. Suppresses atherosclerosis in vivo2. Manzamine A displays neuritogenic activity3 and suppresses tau...

  • Metformin HCl | Anti-diabetic agent
    Metformin HCl (1115-70-4) is a clinically useful antidiabetic agent. Lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis by activation of the AMP-activated protein kinase (AMPK)...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure MG-132 | Proteasome inhibitor | CAS 133407-82-6
    MG-132 (133407-82-6) is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50=100 nM with Z-LLL-AMC as substrate).1 Also inhibits calpain (IC50=1.25 μM).1 Suppresses gastric cancer cell...

  • Niclosamide | STAT3 signaling inhibitor
    Niclosamide (50-65-7) reversibly inhibits mTORC1 signaling and stimulates autophagy1. Inhibits activation and nuclear translocation of STAT3 selectively over STAT1 and STAT5. Niclosamide inhibits transcription of STAT3...

  • Purvalanol A | CDK inhibitor
    Purvalanol A (212844-53-6) is a cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1 Reversibly arrests...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Rapamycin | mTOR inhibitor | CAS 53123-88-9
    Rapamycin (53123-88-9) is a clinically useful immunosuppressant. Inhibits the response to interleukin-2 blocking activation of T- and B-cells.1 Rapamycin forms a complex with cytosolic FK-binding protein 12 (FKB12) that...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Rottlerin | PKCdelta inhibitor | CAS 82-08-6
    Rottlerin (82-08-6) has been reported to inhibit PKCδ selectively however this result has been called into question.1 Displays neuroprotective effects.2 Induces autophagy.3 Cell permeable...

  • Salinomycin Na | Cancer stem cell inhibitor
    Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma...

  • Focus Biomolecules supplier, structure of Spautin-1 | Inhibits autophagy by inhibiting USP 10 & 13 | CAS 1262888-28-7
    Spautin-1 (1262888-28-7) is a specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of STF-62247 | Autophagy inducer | CAS 315702-99-9
    STF-62247 (315702-99-9) specifically induces autophagic cell death in VHL (von Hippel-Lindau)-deficient renal carcinoma cells both in vitro (IC50=625 nM) and in vivo. Renal cell carcinoma cell lines were radiosensitized by...

  • Temozolomide | Autophagy inducer
    Temozolomide (85622-93-1) is a DNA alkylating agent with antitumor and antiangiogenic activity.1,2 Clinically useful anticancer agent.3 Temozolomide induces autophagy in a variety of cell lines.4 Cell...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Thapsigargin | SERCA inhibitor | CAS 67526-95-8
    Thapsigargin (67526-95-8) is a potent inhibitor of sarco-endoplasmic reticulum Ca2+ -ATPase1. (IC50= 30 nM) Induces endoplasmic reticulum stress and autophagy in a variety of cell lines2. Warning: Thapsigargin is highly...

  • Tunicamycin | ER stress inducer
    Tunicamycin (11089-65-9) is a fermentation product from Streptomyces lysosuperificus.  Provided as a mixture of tunicamycin A (C14), B (C15), C (C16) and D (C17) homologs varying in the number of carbon atoms in the...

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