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UPR

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure 4μ8C | IRE1 ribonuclease inhibitor | CAS 14003-96-4
    $75.00
    4μ8C (14003-96-4) is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Azoramide | UPR modulator | CAS 932986-18-0
    $50.00
    Azoramide (932986-18-0) is a modulator of the unfolded protein response (UPR).1  It improves endoplasmic reticulum (ER) protein folding and activates ER chaperone capacity to protect cells against ER stress. It...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of STF-083010 | IRE1 inhibitor | CAS 307543-71-1
    $45.00
    STF-083010 (307543-71-1) is a novel small molecule inhibitor of IRE1. It inhibits IRE1 endonuclease activity but not its kinase activity after endoplasmic reticulum stress1-3. It displays significant antimyeloma activity in...

  • Focus Biomolecules supplier, chemical structure of Toyocamycin | Unfolded protein response (UPR) inhibitor | CAS 606-58-6
    $70.00
    Toyocamycin (606-58-6) is an adenosine analog which inhibits ribozyme self cleavage in mammalian cells, EC50 = 0.4 μM (for expression of a luciferase reporter).1 A potent inhibitor of ER stress-induced XBP1 mRNA splicing...

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