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Chloroquine phosphate | autophagy inhibitor

Chloroquine phosphate (50-63-5) is an antimalarial drug. Inhibits autophagy in a variety of cell lines1. Induces cell death in breast cancer cell lines and displays antitumor and antimetastatic activity in mouse models of breast cancer2. Eliminates cancer stem cells via deregulation of Jak2 and DNMT13. Chloroquine phosphate displays synergy when combined with the Raf inhibitor, vemurafenib, in brain tumor4. Cell permeable and active in vivo.

References/Citations
1) Frieboes et al. (2014), Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy; JOP, 15 189
2) Jiang et al. (2010), Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer; Biomed. Pharmacother., 64 609
3) Choi et al. (2014), Chloroquine eliminates cancer stem cells through deregulation of Jak2 and DNMT1; Stem Cells, 32 2309
4) Mulcahy Levy et al. (2014), Autophagy inhibition improves chemosensitivity in BRAFV600E brain tumors; Cancer Discov., 4 773

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Catalog#  10-2473

$25.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
50-63-5
Catalog Number:
10-2473
Activity:
autophagy inhibitor
Chemical Name:
N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine, diphosphate
Molecular Weight:
515.87
Molecular Formula:
C18H26ClN3 2H3PO4
Solubility:
Soluble in Water (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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