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Citalopram HBr | Serotonin uptake inhibitor

Citalopram (59729-32-7) is a potent and selective serotonin uptake inhibitor (SSRI) Ki=5.4 nM. Has no effect on norepinephrine or dopamine uptake.1 Displays cardioprotective effects in part by reducing expression of cytokine-induced endothelial adhesion molecules, ICAM-1 and VCAM-1.2 Clinically useful antidepressant.3 Attenuates ethanol intake.4

 

References/Citations

1) Mateo et al. (2000), Inhibition of 5-hydroxytryptamine reuptake by the antidepressant citalopram in the locus coeruleus modulates the rat brain noradrenergic transmission in vivo; Neuropharmacology 39 2036
2) Lekakis et al. (2010), Selective serotonin re-uptake inhibitors decrease the cytokine-induced endothelial adhesion molecule expression, the endothelial adhesiveness to monocytes and the circulating levels of vascular adhesion molecules; Int. J. Cardiol. 139 150
3) Cipriani et al. (2009), Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis; Lancet 373 746
4) Naranjo et al. (1987), The serotonin uptake inhibitor citalopram attenuates ethanol intake; Clin. Pharmacol. Ther. 41 266

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Catalog#  10-2458-0010

$70.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
59729-32-7
Catalog Number:
10-2458
Activity:
Serotonin uptake inhibitor
Chemical Name:
1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide
Molecular Weight:
405.31
Molecular Formula:
C20H21FN2O HBr
Solubility:
Soluble in Water (up to 4 mg/ml), DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in water, DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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