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GTPase

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Dynasore | Dynamin inhibitor | CAS 304448-55-3
    Dynasore | Dynamin inhibitor
    $40.00
    Dynasore (304448-55-3) is a noncompetitive inhibitor of dynamin GTPase activity and blocks dynamin-dependent endocytosis in cells, including neurons. It inhibits the GTPase activity of dynamin1, dynamin2, and Drp1...

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  • EPAC 5376753 | Structure | Supplier
    EPAC 5376753 | EPAC inhibitor
    $60.00
    EPAC 5376753 is an allosteric inhibitor of Epac1, IC50= 4 μM.1 Does not inhibit PKA or adenylyl cyclase. Inhibits biological functions mediated by Epac including cAMP-induced increase in migration of cardiac fibroblasts...

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  • Focus Biomolecules cell signaling reagent supplier, structure Mdivi | Mitochondrial division inhibitor | CAS 338967-87-6
    Mdivi | Mitochondrial division inhibitor
    $40.00
    Mdivi (338967-87-6) is a selective inhibitor of Dnm1 GTPase (IC50=1-10 μM). Inhibits mitochondrial outer membrane permeabilization. Mdivi inhibits mitochondrial division and apoptosis. Cell permeable...

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  • MiTMAB | Dynamin inhibitor
    MiTMAB | Dynamin inhibitor
    $55.00
    MiTMAB (1119-97-7) is a dynamin I/II inhibitor targeting the dynamin-phospholipid interaction and inhibiting dynamin GTPase activity with a Ki=940nM.1 Rapidly and reversibly inhibits multiple forms of endocytosis with no...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MLS-532223 | GTPase inhibitor | CAS 16616-39-0
    MLS-532223 | GTPase inhibitor
    $62.00
    MLS-532223 is a high-affinity selective inhibitor of Rho family GTPases (EC50=10 μM). It inhibits EGF-stimulated Rac1 activation (3-10 μM). Cell permeable. References/Citations1) Surviladze et al. (2010),...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MLS-573151 | Cdc42 inhibitor | CAS 10179-57-4
    MLS-573151 | Cdc42 inhibitor
    $65.00
    MLS-573151 (10179-57-4) is a potent and specific inhibitor of Cdc42 a small GTPase of the Rho-subfamily (IC50=2 μM).1 A useful agent fpr probing the involvement of Cdc42 in cellular signaling and physiology.2...

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  • Nocodazole | Microtubule inhibitor
    Nocodazole | Microtubule inhibitor
    $50.00
    Nocodazole (31430-18-9) is an antimitotic agent that disrupts microtubules by binding to β tubulin and thereby inhibiting microtubule dynamics, disruption of mitotic spindle function, and fragmentation of the Golgi...

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  • NSC-23766 | Rac1 GTPase inhibitor
    NSC-23766 | Rac1 GTPase inhibitor
    $67.00
    NSC-23766 (733767-34-5) is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) Trio and Tiam1 (IC50 ca. 50 μM) with no effect on the closely...

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  • Salirasib | 162520-00-5 | Structure | Supplier
    Salirasib | Ras inhibitor
    $30.00
    Salirasib (162520-00-5) is a synthetic farnesylcysteine mimetic that inhibits ras proteins1,2 via disruption of interactions between the S-Prenyl moiety of Ras and the membrane anchorage domains3.  It has been...

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  • Focus Biomolecules supplier, chemical structure of Thiostrepton | Antibiotic and FOXM1 inhibitor | CAS 1393-48-2
    Thiostrepton | Antibiotic and FOXM1 inhibitor
    $85.00
    Thiostrepton (1393-48-2) is a novel cyclopeptide antibiotic. Blocks bacterial protein synthesis by inhibition of mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery as well as...

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