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Product Details

Mithramycin A | Transcription inhibitor

Mithramycin A (18378-89-7) inhibits DNA methyl transferase.1 A selective Sp1 inhibitor, it binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, inhibiting their expression.2 Mithramycin A (at 10-200 nM) sensitizes tumor cells to TRAIL-induced apoptosis.3


1) Lin et al. (2007), Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells; Anticancer Drugs, 18 1157
2) Jia et al. (2010), Combined treatment of pancreatic cancer cells with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic anti-tumor activity; Cancer Res., 70 1111
3) Lee et al. (2006), Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites; Mol. Cancer Ther., 5 2737

Focus Biomolecules cell signaling supplier, chemical structure of Mithramycin A | Transcription inhibitor | CAS 18378-89-7

Catalog#  10-2085-0001

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
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Catalog Number:
Transcription inhibitor
Alternate Names:
A2371; Antibiotic LA 7017; Aureolic Acid; NSC 24559; PA 144; Plicamycin
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml)
Physical Properties:
Yellow solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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