NVP-231 | Ceramide kinase inhibitor

NVP-231 (362003-83-6) is a reversible inhibitor of ceramide kinase (IC50 = 12 nM).1 At 10 nM, it inhibited ceramide-1-phosphate formation by >50% and at 100 nM it completely inhibited its formation in cell culture.  NVP-231 was inactive against hSphK1/2, hPI3Ka, hPI4Kb, hVps34, hGCS, hSMS-1, CERT, and 500-fold less potent against hDAGKa.  NVP-231 inhibited breast and lung cancer cell proliferation via M phase arrest.2 It potently blocked cell migration and invasion in PANC-1 pancreatic cancer cells3 as well as MDA-MB-231 breast cancer cells4.

  1. Graf et al. (2008), Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor; Pharmacol., 74 925
  2. Pastukhov et al. (2014), The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death; Br. J. Pharmacol., 171 5829
  3. Rivera et al. (2016), Ceramide-1-phosphate regulates cell migration and invasion of human pancreatic cancer cells; Biochem. Pharmacol., 102 107
  4. Schwalm et al. (2020), Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI3-Kinase and Akt; Int. J. Mol. Sci., 21 1396
Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size:

5 mg, 25 mg

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CAS:
362003-83-6
Catalog Number:
10-4694
Activity:
Reversible ceramide kinase inhibitor
Chemical Names:
N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide
Molecular Weight:
431.55
Molecular Formula:
C25H25N3O3S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

NVP-231 | Ceramide kinase inhibitor

$40.00$130.00

CAS:
362003-83-6
Catalog Number:
10-4694
Activity:
Reversible ceramide kinase inhibitor
Chemical Names:
N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide
Molecular Weight:
431.55
Molecular Formula:
C25H25N3O3S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
  • 5 mg
  • 25 mg
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