my account
  Loading... Please wait...

Product Details

POB | Ornithine decarboxylase inhibitor

POB is a transition state-based, cell permeable pro-drug inhibitor of ODC, a key enzyme involved in polyamine synthesis and a potential cancer drug target. Intracellularly, POB is phosphorylated by pyridoxal kinase and the methyl ester hydrolyzed. This active inhibitor most likely binds apo-ODC resulting in greatly reduced ODC activity and inhibition of cellular proliferation. POB was able to inhibit proliferation in a wide variety of tumor cell lines: LN229 (IC50 = 50 μM), Jurkat, COS7, SW2 and both high and low-grade glioblastoma multiforme. More potent than DFMO.

1) Wu et al. (2007), New transition state-based inhibitor for human ornithine decarboxylase inhibits growth of tumor cells; Mol. Cancer Ther., 6 1831
2) Wu et al. (2011), A novel approach to inhibit intracellular vitamin B6-dependent enzymes: proof of principle with human and plasmodium ornithine decarboxylase and human histidine decarboxylase; FASEB J., 25 2109

Focus Biomolecules cell signaling supplier, chemical structure of POB | Ornithine decarboxylase inhibitor | CAS 946135-39-3

Catalog#  10-4553

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Request Bulk Quote
Catalog Number:
Ornithine decarboxylase inhibitor
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml), in Water (up to 2 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
98% by HPLC
NMR (Confirms)
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. Solutions in distilled water are not stable and must be made fresh and used within one working day.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the POB | Ornithine decarboxylase inhibitor to your wish list.