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POB | Ornithine decarboxylase inhibitor

POB is a transition state-based, cell permeable pro-drug inhibitor of ODC, a key enzyme involved in polyamine synthesis and a potential cancer drug target. Intracellularly, POB is phosphorylated by pyridoxal kinase and the methyl ester hydrolyzed. This active inhibitor most likely binds apo-ODC resulting in greatly reduced ODC activity and inhibition of cellular proliferation. POB was able to inhibit proliferation in a wide variety of tumor cell lines: LN229 (IC50 = 50 μM), Jurkat, COS7, SW2 and both high and low-grade glioblastoma multiforme. More potent than DFMO.

References/Citations
1) Wu et al. (2007), New transition state-based inhibitor for human ornithine decarboxylase inhibits growth of tumor cells; Mol. Cancer Ther., 6 1831
2) Wu et al. (2011), A novel approach to inhibit intracellular vitamin B6-dependent enzymes: proof of principle with human and plasmodium ornithine decarboxylase and human histidine decarboxylase; FASEB J., 25 2109

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Focus Biomolecules cell signaling supplier, chemical structure of POB | Ornithine decarboxylase inhibitor | CAS 946135-39-3

Catalog#  10-4553

$70.00
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CAS:
946135-39-3
Catalog Number:
10-4553
Activity:
Ornithine decarboxylase inhibitor
Chemical Name:
N-(4'-Pyridoxyl)-L-Ornithine(BOC)-Ome
Molecular Weight:
397.47
Molecular Formula:
C19H31N3O6
Solubility:
Soluble in DMSO (up to 25 mg/ml), in Water (up to 2 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Confirms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. Solutions in distilled water are not stable and must be made fresh and used within one working day.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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