my account
Login
  Loading... Please wait...

Product Details

Z-VAD-FMK | Caspase inhibitor

Z-VAD-FMK (187389-52-2), cell-permeable, methyl ester form. Potent, irreversible pan-caspase inhibitor. Inhibits caspase activity and apoptosis induction in a variety of cell types (IC50 = 1.5 μM). Active in vivo.

References/Citations
1) Slee et al. (1996), Benzyloxycarbonyl-Val-Ala-ASP (OMe) fluoromethylketone (Z-VAD-FMK) inhibits apoptosis by blocking the processing of CPP32; Biochem. J., 315 21
2) Kunstle et al. (1997), ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha; Immunol. Lett., 55 5
3) Garcia-Calvo et al. (1998), Inhibition of human caspases by peptide based and macromolecular inhibitors; J. Biol. Chem., 273 32608

swipe
Focus Biomolecules cell signaling reagent supplier, chemical structure of Z-VAD-FMK | Caspase inhibitor | CAS 187389-52-2

Catalog#  10-2614

$98.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
187389-52-2
Catalog Number:
10-2614
Activity:
Caspase inhibitor
Alternate Names:
ZVAD(OMe)-FMK
Chemical Name:
Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
Molecular Weight:
467.5
Molecular Formula:
C22H30FN3O7
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
Lyophilized or waxy solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the Z-VAD-FMK | Caspase inhibitor to your wish list.