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Approved Drugs

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  • 6-Thioguanine | Anticancer agent / Downregulates DNMT1
    $30.00
    6-Thioguanine (154-42-7) is a methyltransferase inhibitor.  After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It...

  • Afatinib | EGFR and HER2 inhibitor
    $85.00
    Afatinib (850140-72-6) is a clinically useful kinase inhibitor approved for the treatment of non-small cell lung cancer. It is a potent and highly selective inhibitor of mutant and wild-type EGFR (IC50= 0.5 nM) and HER2...

  • Ambroxol HCl | Free radical scavenger
    $50.00
    Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in...

  • Amifostine | Cellular protectant
    $56.00
    Amifostine (20537-88-6) is a broad sprectrun radio- and chemoprotective agent.1 Prevents chemotherapy-induced apoptosis, upregulates HIF-1α and restores transcriptional activity in specific p53 mutants...

  • Amiodarone HCl | PDE inhibitor
    $45.00
    Amiodarone HCl (19774-82-4) is a pan-specific inhibitor of phosphodiesterases (IC50=2-50 μM). Inhibition of PDEs leads to increased concentration of intracellular cAMP which activates PKA2. Does not inhibit PDE8 or PDE93...

  • Apomorphine HCl | 41372-20-7 | Structure | Supplier
    $40.00
    Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse model.2 In clinical use for Parkinson’s...

  • Aripiprazole | Dopamine receptor partial agonist
    $40.00
    Aripiprazole (129722-2-9) is a clinically useful neuroleptic and antipsychotic agent.1 Dopamine D2 receptor antagonist and autoreceptor agonist.2 Improves symptoms of psychosis associated with Alzheimer's disease...

  • Auranofin | IKK inhibitor
    $50.00
    Auranofin (34031-32-8) is a disease-modifying antirheumatic drug (DMARD) , It is a potent inhibitor of selenoenzyme thioredoxin reductase and IκB kinase (IKK) by modifying Cys-179. Auranofin is an efficient inducer of...

  • Axitinib | VEGFR kinase inhibitor
    $40.00
    Axitinib (319460-85-0) is a potent inhibitor of VEGFR-2, -3, and -1, IC50 = 0.2, 0.1-0.3, and 1.2 nM respectively1 displaying minimal activity against a panel of ~100 protein kinases. Inhibits angiogenesis and vascular...

  • Bleomycin sulfate | Fibrosis-inducing agent
    $90.00
    Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Commonly used to induce lung fibrosis in animal disease models.3,4 Anticancer agent in...

  • Captopril | Angiotensin-converting enzyme inhibitor
    $30.00
    Captopril (62571-86-2) is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.022 μM).1 Also inhibits the bifunctional Zn2+-containing leukotriene A4 hydrolase/aminopeptidase (LTA4 hydrolase) reversibly and...

  • Chloroquine phosphate | autophagy inhibitor
    $25.00
    Chloroquine phosphate (50-63-5) is an antimalarial drug. Inhibits autophagy in a variety of cell lines1. Induces cell death in breast cancer cell lines and displays antitumor and antimetastatic activity in mouse models of...

  • Cilostazol | 73963-72-1 | Structure | Supplier
    $60.00
    Cilostazol (73963-72-1) is a clinically approved phosphodiesterase III (PDE3) inhibitor (IC50 = 0.2 μM) and anti-thrombotic agent. It inhibits platelet aggregation and is a direct arterial vasodilator...

  • Cisplatin | Anticancer agent
    $50.00
    Induces intra- and interstrand DNA adducts which poison topoisomerase I.1 Synergizes with topoisomerase I inhibitors such as topotecan.1 Induces apoptosis by sequential activation of caspase-8, -3 and -6 in osteosarcoma...

  • Clodronate 2Na | Induces osteoclast apoptosis
    $30.00
    Clodronate 2Na (88416-50-6) is a first generation non-nitrogenous bisphosphonate drug for the prevention and treatment of osteoporosis and skeletal fractures/hypercalcemia in patients with cancer.  It strongly binds to...

  • Clozapine | 5786-21-0 | Structure | Supplier
    $30.00
    Clozapine (5786-21-0) is a dopamine D4 and D2 receptor antagonist. High affinity for the cloned rat dopamine D4 receptor (Ki < 20 nM).1 Atypical neuroleptic agent.2 Antagonist at 5HT2A, 5HT2C, 5HT3, 5HT6 and 5HT7...

  • Colchicine | Microtubule depolymerizer
    $40.00
    Colchicine (64-86-8) is a naturally occurring alkaloid which acts as an antimitotic agent by binding to tubulin and depolymerizing microtubules. Colchicine induces apoptosis in a variety of cell lines...

  • Cycloserine, D(+) | NMDA, glycine site partial agonist
    $60.00
    D-Cycloserine (68-41-7) is a partial agonist at the glycine modulatory site of NMDA glutamatergic receptors.1 Blocks kainate-induced seizures2 and displays anticonvulsant effects3 in rat models. D-Cycloserine facilitates...

  • Dabrafenib | B-Raf mutant inhibitor
    $34.00
    Dabrafenib (1195765-45-7) is a selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50 = 3.2 and 5 nM, respectively).1 Has been in clinical...

  • Dantrolene Na | SR calcium release inhibitor
    $50.00
    Dantrolene Na (14663-23-1) inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor channels with selectivity for RYR1 and RYR3 over RYR2.1 Protects against quisqualate and NMDA-induced...

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