5-Fluorouridine (316-46-1) is an inhibitor of ribozyme self-cleavage in mammalian cells.1 Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms besides global inhibition of RNA synthesis and processing contribute to 5-fluorouridine cytotoxicity.2 Cell permeable and active in vivo.
1) Yen et al. (2006), Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries; RNA, 12 797
2) Schmittgen et al. (2005), Diverse gene expression pattern during 5-fluorouridine-induced apoptosis; Int. J. Oncol., 27 297