Modify Search
Select all
Products
Pages
Posts
Modify Search
Select all
Products
Pages
Posts

5-Fluorouridine | Proapoptotic antiproliferative agent

CAS:
316-46-1
Catalog Number:
10-1277
Activity:
Proapoptotic antiproliferative agent
Chemical Name:
1-(β-D-Ribofuranosyl)-5-fluorouracil
Alternate Names:
FUrd
Molecular Weight:
262.19
Molecular Formula:
C9H11FN2O6
Solubility:
Soluble in DMSO (up to 50 mg/ml), in Water (up to 50 mg/ml), or in Ethanol (up to 6 mg/ml with warming)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

5-Fluorouridine (316-46-1) is an inhibitor of ribozyme self-cleavage in mammalian cells.1  Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms besides global inhibition of RNA synthesis and processing contribute to 5-fluorouridine cytotoxicity.2 Cell permeable and active in vivo.

References/Citations:

1) Yen et al. (2006), Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries; RNA, 12 797
2) Schmittgen et al. (2005), Diverse gene expression pattern during 5-fluorouridine-induced apoptosis; Int. J. Oncol., 27 297

5-Fluorouridine | Proapoptotic antiproliferative agent is also available in the Cellular Metabolism Library.
CAS:
316-46-1
Catalog Number:
10-1277
Activity:
Proapoptotic antiproliferative agent
Chemical Name:
1-(β-D-Ribofuranosyl)-5-fluorouracil
Alternate Names:
FUrd
Molecular Weight:
262.19
Molecular Formula:
C9H11FN2O6
Solubility:
Soluble in DMSO (up to 50 mg/ml), in Water (up to 50 mg/ml), or in Ethanol (up to 6 mg/ml with warming)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

N/A
Add to Quote

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee