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Stem Cells

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  • BRD 7116 | 329059-55-4 | Structure
    BRD 7116 (329059-55-4) inhibits leukemia stem cell (LSC) activity (EC50 = 200 nM). Displays a >100-fold selectivity for LSCs over normal hematopoietic stem cells.1 References/Citations 1) Hartwell et al. (2013),...

  • Chloroquine phosphate | autophagy inhibitor
    Chloroquine phosphate (50-63-5) is an antimalarial drug. Inhibits autophagy in a variety of cell lines1. Induces cell death in breast cancer cell lines and displays antitumor and antimetastatic activity in mouse models of...

  • Cyclopamine | 4449-51-8 | Structure | supplier
    Cyclopamine (4449-51-8) is a naturally occurring steroidal alkaloid with teratogenic activity. Blocks sonic hedgehog signaling by binding to smoothened. Antitumor activity. Cell Permeable. References/Citations1) Watkins et...

  • Echinomycin | HIF-1alpha inhibitor
    Echinomycin is a potent and selective hypoxia inducible factor 1α (HIF-1α) inhibitor. It binds to DNA via bifunctional intercalation, blocking the interaction of HIF-1α.1 Protects mice against relapsed...

  • Harmine | MAO-A and DYRK inhibitor
    Harmine (343-27-1) is a selective competitive and reversible inhibitor of MAO-A (IC50 = 8 μM).1 Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation...

  • ICG-001 | Wnt  beta-catenin inhibitor
    ICG-001 (847591-62-2) inhibits TCF/β-catenin mediated transcription by specifically blocking β-catenin/CBP interaction References/Citations 1) Emami et al. (2004), A small molecule inhibitor of...

  • ML-239 | 1378872-36-6 | Structure | Supplier
    ML-239 (1378872-36-6) novel inhibitor of the growth and proliferation of breast cancer stem cells (CSC) discovered in a phenotypic screen employing CSC-like cells produced by inducing human breast epithelial cells into an...

  • Reparixin | CXCR 1/2 allosteric antagonist
    Reparixin is a noncompetitive allosteric inhibitor of IL-8 (CXCL8) activation of CXCR1 and CXCR2 chemokine receptors (IC50 = 1 and 100 nM, respectively). It blocks a number of activities related to IL-8 signaling, including...

  • Salinomycin Na | Cancer stem cell inhibitor
    Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma1...

  • Vismodegib | Sonic Hedgehog signaling pathway inhibitor
    A potent and selective Hedgehog (Hh) pathway signaling inhibitor antagonizing SMO with a Ki of 1.3 nM).1 Alters intracellular Ca2+ homeostasis and inhibits growth of cisplatin-resistant lung cancer cells.2  Inhibits two...

  • Wnt-C59 | Porcupine Inhibitor
    Wnt-C59 (1243243-89-1) is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase.1 Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms.  It was able to block progression of...

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